Effects of neridronate treatment in elderly women with osteoporosis

T. Cascella, T. Musella, F. Orio, S. Palomba, G. Bifulco, C. Nappi, G. Lombardi, A. Colao, L. Tauchmanova

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Osteoporosis is a common disorder, especially among elderly post-menopausal women. Elderly women are often affected by co-morbidities, impaired gastrointestinal function and reduced mobility; therefore, the treatment strategy for their osteoporosis can be difficult. In this randomized pilot study, we have investigated the effects of a 12-month treatment with neridronate on bone mineral density (BMD), bone turnover markers and quality of life (QoL). The study included 40 women (age, 65-80 yr; post-menopausal period, >15yr) from a single osteoporosis centre. Twenty women received a monthly im injection of 25 mg of neridronate associated with a daily dose of 500 mg of calcium and 400 U of vitamin D. Twenty women received calcium plus vitamin D supplements alone. Changes in BMD at the lumbar spine and femoral neck were measured by dual energy X-ray absorptiometry. Serum type I collagen C-telopeptide (sCTX), urinary free-deoxypyridinoline (ufDPD), bone alkaline phosphatase (ALP) and serum osteocalcin levels were determined. For the QoL assessment, the Italian version of the SF-36 test was administrated. Spine and hip BMD rose by 6.6±3 and 4.2±2.3%, respectively (p

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalJournal of Endocrinological Investigation
Issue number3
Publication statusPublished - 2005



  • Bone mineral density
  • Bone turnover
  • Elderly women
  • Neridronate
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology

Cite this

Cascella, T., Musella, T., Orio, F., Palomba, S., Bifulco, G., Nappi, C., Lombardi, G., Colao, A., & Tauchmanova, L. (2005). Effects of neridronate treatment in elderly women with osteoporosis. Journal of Endocrinological Investigation, 28(3), 202-208.