The effectiveness of chronic treatment with nifedipine in patients with a history of stable angina on effort has been evaluated in a double-blind study in 15 subjects of both sexes, aged 45 to 65 yr. All patients underwent diagnostic cardiac catheterization and selective coronary angiography, which showed stenosis of one or two main coronary vessels between 50 and 70%. The patients, after 2 wk of observation, underwent erect bicycle exercise test with increasing workloads. After 4 wk of treatment with nifedipine or placebo, the stress test was repeated. Nifedipine treatment reduced the weekly number of anginal attacks as well as the weekly number of nitroglycerin tablets consumed by the patients, increased maximum workload tolerated and reduced the S-T segment depression for the same workload, meanwhile heart rate and blood pressure did not change significantly either at rest or during exercise. The result of this study indicates that nifedipine is useful in the treatment of patients with stable angina on effort.
|Translated title of the contribution||Effects of nifedipine in the treatment of effort stable angina: a double blind study|
|Number of pages||5|
|Journal||Giornale Italiano di Cardiologia|
|Publication status||Published - 1978|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine