Effects of nimesulide on nitric oxide-induced hyperalgesia in humans - A neurophysiological study

Giorgio Sandrini, Cristina Tassorelli, Alberto Proietti Cecchini, Enrico Alfonsi, Giuseppe Nappi

Research output: Contribution to journalArticle

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce analgesia mainly via the inhibition of cyclo-oxygenase. Several reports suggest that chronic pain is mediated by central sensitization, an N-methyl-D-aspartate (NMDA)-mediated phenomenon influenced by cyclo-oxygenase activity and nitric oxide (NO). In this double-blind study, we evaluated the effects of a preferential inhibitor of the inducible isoform of cyclo-oxygenase-2, nimesulide, on the spinal nociceptive flexion reflex (RIII reflex) before and after administration of an NO donor in healthy volunteers. Nimesulide caused a reduction of the RIII reflex area, which persisted after NO donor administration. Conversely, in the placebo group the RIII reflex area significantly increased following the administration of the NO donor. These data suggest a central effect for nimesulide, possibly related to a reduction of nociceptive activity at spinal level.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalEuropean Journal of Pharmacology
Volume450
Issue number3
DOIs
Publication statusPublished - Aug 30 2002

Keywords

  • Cyclo-oxygenase
  • Nimesulide
  • Nitric oxide (NO)
  • Pain
  • RIII threshold

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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