Abstract
The effects of nitrendipine (10 mg b.i.d.) on blood pressure, renin-angiotensin-aldosterone system, and kidney function (by means of glomerular and tubular function) were studied in comparison to captopril (50 mg b.i.d.) and to nitrendipine (10 mg q.d.) + captopril (25 mg b.i.d.) in 30 untreated essential mild-to-moderate hypertensives. The blood pressure lowering effect was similar with either regimen. Nitrendipine showed an acute and chronic natriuretic effect not accompanied by modifications of kidney function. All regimens were well tolerated by the patients without any appreciable side effects over the 4-week study period.
| Original language | English |
|---|---|
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 12 |
| Issue number | SUPPL. 4 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology
Cite this
Effects of nitrendipine on blood pressure, renin-angiotensin system, and kidney function in essential hypertension. / Glorioso, N.; Manunta, P.; Troffa, C.; Pazzola, A.; Soro, A.; Pala, F.; Melis, M. G.; Madeddu, P.; Tonolo, G.
In: Journal of Cardiovascular Pharmacology, Vol. 12, No. SUPPL. 4, 1988.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effects of nitrendipine on blood pressure, renin-angiotensin system, and kidney function in essential hypertension
AU - Glorioso, N.
AU - Manunta, P.
AU - Troffa, C.
AU - Pazzola, A.
AU - Soro, A.
AU - Pala, F.
AU - Melis, M. G.
AU - Madeddu, P.
AU - Tonolo, G.
PY - 1988
Y1 - 1988
N2 - The effects of nitrendipine (10 mg b.i.d.) on blood pressure, renin-angiotensin-aldosterone system, and kidney function (by means of glomerular and tubular function) were studied in comparison to captopril (50 mg b.i.d.) and to nitrendipine (10 mg q.d.) + captopril (25 mg b.i.d.) in 30 untreated essential mild-to-moderate hypertensives. The blood pressure lowering effect was similar with either regimen. Nitrendipine showed an acute and chronic natriuretic effect not accompanied by modifications of kidney function. All regimens were well tolerated by the patients without any appreciable side effects over the 4-week study period.
AB - The effects of nitrendipine (10 mg b.i.d.) on blood pressure, renin-angiotensin-aldosterone system, and kidney function (by means of glomerular and tubular function) were studied in comparison to captopril (50 mg b.i.d.) and to nitrendipine (10 mg q.d.) + captopril (25 mg b.i.d.) in 30 untreated essential mild-to-moderate hypertensives. The blood pressure lowering effect was similar with either regimen. Nitrendipine showed an acute and chronic natriuretic effect not accompanied by modifications of kidney function. All regimens were well tolerated by the patients without any appreciable side effects over the 4-week study period.
UR - http://www.scopus.com/inward/record.url?scp=0024271481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024271481&partnerID=8YFLogxK
M3 - Article
C2 - 2468859
AN - SCOPUS:0024271481
VL - 12
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - SUPPL. 4
ER -