In 15 patients with coronary artery disease who underwent hemodynamic studies, pressure measurements and left ventricular angiography were performed prior and 5' after the administration of 0.4 mg of spray nitroglycerin (TNG). Two different expressions of left ventricular diastolic compliance (dV/dP(.) V at end-diastole, ΔV/ΔP normalized by end-systolic volume-VTS) were assessed in basal conditions and after TNG. Nitroglycerin decreased left ventricular end-diastolic pressure (control 22.7 ± 7.6 mmHg; TNG 11.4 ± 6.1 mmHg, p <0.001) left ventricular end-diastolic volume (control 138 ± 54 ml/m 2, TNG 122 ± 54 ml/m 2, p <0.001) and improved compliance indexes (dV/dP (.) V(ed) control 1.3 ± 10 -2/mmHg; TNG 4.6 ± 4.3 10 -2/mmHg; p <0.01; ΔV/ΔP(.) VTS control 0.071 ± 0.04 mmHg -1; TNG 0.170 ± 0.14 mmHg -1, p <0.01). TNG decreased the average value of modulus of chamber stiffness K (control 0.031 ± 0.009; TNG 0.028 ± 0.008, p <0.02) shifting the pressure-volume curve in some patients rightward and downward. Thus the increase of end-diastolic compliance (dV/dP (.) V(ed) is due to preload reduction and in patients who presented a marked decrease in K, also to the shift of the pressure-volume relation. These effects of TNG have important implications because they permit patients with coronary artery disease to engage in a given effort at a significantly lower end-diastolic pressure, avoiding pulmonary congestion.
|Translated title of the contribution||Effects of nitroglycerin on the left ventricular diastolic pressure volume relations in the coronary artery disease patients|
|Number of pages||7|
|Journal||Giornale Italiano di Cardiologia|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine