Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75

Valentina Carito, Alessandro Venditti, Armandodoriano Bianco, Mauro Ceccanti, Anna Maria Serrilli, George Chaldakov, Luigi Tarani, Sara De Nicolò, Marco Fiore

Research output: Contribution to journalArticle

Abstract

In this study, we evaluated, in the mouse, the effects of 20 mg/kg i.p. daily administration for 15 consecutive days of a blend of polyphenols, containing mostly oleuropein, extracted from the olive leaves (Olea europaea) on brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and on the expression of their receptors, TrkA, TrkB and p75. Polyphenols decreased the levels of reduced glutathione (GSH) and increased the levels of NGF and BDNF in the serum. In the brain, we found decreased levels of NGF and BDNF in the hippocampus and striatum but elevated levels of NGF in the olfactory lobes and hypothalamus and again BDNF potentiation in the olfactory lobes. No changes in TrkA, TrkB and p75 expression were observed. In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.

Original languageEnglish
Pages (from-to)1970-1984
Number of pages15
JournalNatural Product Research
Volume28
Issue number22
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • BDNF
  • NGF
  • olive
  • polyphenols

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry
  • Medicine(all)

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  • Cite this

    Carito, V., Venditti, A., Bianco, A., Ceccanti, M., Serrilli, A. M., Chaldakov, G., Tarani, L., De Nicolò, S., & Fiore, M. (2014). Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75. Natural Product Research, 28(22), 1970-1984. https://doi.org/10.1080/14786419.2014.918977