Abstract
In order to assess the overall impact of PUFA ω-3 supplementation on cardiovascular risk, the effects of such a supplementation on blood pressure, plasma lipoproteins and in vitro and in vivo LDL oxidizability have been evaluated in a group of patients with primary endogenous hypertriglyceridemia. After a period on a standard hypolipidemic diet, patients were randomly allocated to treatment with an individually-tailored diet either alone or supplemented with PUFA ω-3. PUFA ω-3 supplementation, but not diet alone, induced a significant reduction in diastolic blood pressure and plasma triglycerides, but was also associated with an enhanced susceptibility of LDL to in vitro oxidation. Moreover, the anti-oxidized LDL IgG autoantibody titer rose during treatment with PUFA ω-3, thus suggesting an increased LDL oxidation actually taking place in vivo. Although the effects on blood pressure and plasma triglycerides were admittedly favourable, the findings regarding LDL oxidizability are of some concern and suggest a cautious use of PUFA ω-3 supplementation in patients with primary hypertriglyceridemia, unless associated with antioxidants.
| Original language | Italian |
|---|---|
| Pages (from-to) | 87-93 |
| Number of pages | 7 |
| Journal | Rivista Italiana di Biologia e Medicina |
| Volume | 15 |
| Issue number | 3-4 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Medicine(all)
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EFFETTI DELLA SUPPLEMENTAZIONE CON ACIDI GRASSI ω-3 (EPA + DHA) NELL'IPERTRIGLICERIDEMIA PRIMITIVA. / Perani, G.; Maggi, E.; Muggia, C.; Covini, D.; Gallanti, E.; Catalano, O.; Bellomo, G.
In: Rivista Italiana di Biologia e Medicina, Vol. 15, No. 3-4, 1995, p. 87-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - EFFETTI DELLA SUPPLEMENTAZIONE CON ACIDI GRASSI ω-3 (EPA + DHA) NELL'IPERTRIGLICERIDEMIA PRIMITIVA
AU - Perani, G.
AU - Maggi, E.
AU - Muggia, C.
AU - Covini, D.
AU - Gallanti, E.
AU - Catalano, O.
AU - Bellomo, G.
PY - 1995
Y1 - 1995
N2 - In order to assess the overall impact of PUFA ω-3 supplementation on cardiovascular risk, the effects of such a supplementation on blood pressure, plasma lipoproteins and in vitro and in vivo LDL oxidizability have been evaluated in a group of patients with primary endogenous hypertriglyceridemia. After a period on a standard hypolipidemic diet, patients were randomly allocated to treatment with an individually-tailored diet either alone or supplemented with PUFA ω-3. PUFA ω-3 supplementation, but not diet alone, induced a significant reduction in diastolic blood pressure and plasma triglycerides, but was also associated with an enhanced susceptibility of LDL to in vitro oxidation. Moreover, the anti-oxidized LDL IgG autoantibody titer rose during treatment with PUFA ω-3, thus suggesting an increased LDL oxidation actually taking place in vivo. Although the effects on blood pressure and plasma triglycerides were admittedly favourable, the findings regarding LDL oxidizability are of some concern and suggest a cautious use of PUFA ω-3 supplementation in patients with primary hypertriglyceridemia, unless associated with antioxidants.
AB - In order to assess the overall impact of PUFA ω-3 supplementation on cardiovascular risk, the effects of such a supplementation on blood pressure, plasma lipoproteins and in vitro and in vivo LDL oxidizability have been evaluated in a group of patients with primary endogenous hypertriglyceridemia. After a period on a standard hypolipidemic diet, patients were randomly allocated to treatment with an individually-tailored diet either alone or supplemented with PUFA ω-3. PUFA ω-3 supplementation, but not diet alone, induced a significant reduction in diastolic blood pressure and plasma triglycerides, but was also associated with an enhanced susceptibility of LDL to in vitro oxidation. Moreover, the anti-oxidized LDL IgG autoantibody titer rose during treatment with PUFA ω-3, thus suggesting an increased LDL oxidation actually taking place in vivo. Although the effects on blood pressure and plasma triglycerides were admittedly favourable, the findings regarding LDL oxidizability are of some concern and suggest a cautious use of PUFA ω-3 supplementation in patients with primary hypertriglyceridemia, unless associated with antioxidants.
KW - polyunsaturated fatty acids
KW - primary hypertriglyceridemia
UR - http://www.scopus.com/inward/record.url?scp=0029553771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029553771&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0029553771
VL - 15
SP - 87
EP - 93
JO - Rivista Italiana di Biologia e Medicina
JF - Rivista Italiana di Biologia e Medicina
SN - 0393-1137
IS - 3-4
ER -