Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

Hartmut Porst; Gerald B. Brock; Krzysztof Kula; Ignacio Moncada; Francesco Montorsi; Bruce R. Basson; Kraig Kinchen; Antonio Aversa

doi:10.2164/jandrol.111.015289

Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

Hartmut Porst, Gerald B. Brock, Krzysztof Kula, Ignacio Moncada, Francesco Montorsi, Bruce R. Basson, Kraig Kinchen, Antonio Aversa

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies established the efficacy of oncedaily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5mg (with possible down-titration to 2.5mg; n=146) or placebo (n=69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21.7% on placebo; P

Original language	English
Pages (from-to)	1305-1322
Number of pages	18
Journal	Journal of Andrology
Volume	33
Issue number	6
DOIs	https://doi.org/10.2164/jandrol.111.015289
Publication status	Published - 2012

Keywords

Drug therapy
Efficacy
Endothelium
Erection
Morning
Nocturnal
Peripheral arterial tonometry
Phosphodiesterases
Psychosocial assessments
Tolerability
Treatment outcome

ASJC Scopus subject areas

Urology
Reproductive Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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Porst, H., Brock, G. B., Kula, K., Moncada, I., Montorsi, F., Basson, B. R., Kinchen, K., & Aversa, A. (2012). Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. Journal of Andrology, 33(6), 1305-1322. https://doi.org/10.2164/jandrol.111.015289

Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. / Porst, Hartmut; Brock, Gerald B.; Kula, Krzysztof et al.

In: Journal of Andrology, Vol. 33, No. 6, 2012, p. 1305-1322.

Research output: Contribution to journal › Article › peer-review

Porst, H, Brock, GB, Kula, K, Moncada, I, Montorsi, F, Basson, BR, Kinchen, K & Aversa, A 2012, 'Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors', Journal of Andrology, vol. 33, no. 6, pp. 1305-1322. https://doi.org/10.2164/jandrol.111.015289

Porst H, Brock GB, Kula K, Moncada I, Montorsi F, Basson BR et al. Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. Journal of Andrology. 2012;33(6):1305-1322. https://doi.org/10.2164/jandrol.111.015289

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abstract = "Previous studies established the efficacy of oncedaily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5mg (with possible down-titration to 2.5mg; n=146) or placebo (n=69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21.7% on placebo; P",

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Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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