Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

Hartmut Porst; Gerald B. Brock; Krzysztof Kula; Ignacio Moncada; Francesco Montorsi; Bruce R. Basson; Kraig Kinchen; Antonio Aversa

doi:10.2164/jandrol.111.015289

Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

Hartmut Porst, Gerald B. Brock, Krzysztof Kula, Ignacio Moncada, Francesco Montorsi, Bruce R. Basson, Kraig Kinchen, Antonio Aversa

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies established the efficacy of oncedaily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5mg (with possible down-titration to 2.5mg; n=146) or placebo (n=69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21.7% on placebo; P

Original language	English
Pages (from-to)	1305-1322
Number of pages	18
Journal	Journal of Andrology
Volume	33
Issue number	6
DOIs	https://doi.org/10.2164/jandrol.111.015289
Publication status	Published - 2012

Keywords

Drug therapy
Efficacy
Endothelium
Erection
Morning
Nocturnal
Peripheral arterial tonometry
Phosphodiesterases
Psychosocial assessments
Tolerability
Treatment outcome

ASJC Scopus subject areas

Urology
Reproductive Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.2164/jandrol.111.015289

Fingerprint Dive into the research topics of 'Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors'. Together they form a unique fingerprint.

Cite this

Porst, H., Brock, G. B., Kula, K., Moncada, I., Montorsi, F., Basson, B. R., Kinchen, K., & Aversa, A. (2012). Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. Journal of Andrology, 33(6), 1305-1322. https://doi.org/10.2164/jandrol.111.015289

Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. / Porst, Hartmut; Brock, Gerald B.; Kula, Krzysztof; Moncada, Ignacio; Montorsi, Francesco; Basson, Bruce R.; Kinchen, Kraig; Aversa, Antonio.

In: Journal of Andrology, Vol. 33, No. 6, 2012, p. 1305-1322.

Research output: Contribution to journal › Article › peer-review

Porst, H, Brock, GB, Kula, K, Moncada, I, Montorsi, F, Basson, BR, Kinchen, K & Aversa, A 2012, 'Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors', Journal of Andrology, vol. 33, no. 6, pp. 1305-1322. https://doi.org/10.2164/jandrol.111.015289

Porst H, Brock GB, Kula K, Moncada I, Montorsi F, Basson BR et al. Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. Journal of Andrology. 2012;33(6):1305-1322. https://doi.org/10.2164/jandrol.111.015289

Porst, Hartmut ; Brock, Gerald B. ; Kula, Krzysztof ; Moncada, Ignacio ; Montorsi, Francesco ; Basson, Bruce R. ; Kinchen, Kraig ; Aversa, Antonio. / Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. In: Journal of Andrology. 2012 ; Vol. 33, No. 6. pp. 1305-1322.

@article{f3292fc0bf824a7e83218cadde5b8314,

title = "Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors",

abstract = "Previous studies established the efficacy of oncedaily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5mg (with possible down-titration to 2.5mg; n=146) or placebo (n=69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21.7% on placebo; P",

keywords = "Drug therapy, Efficacy, Endothelium, Erection, Morning, Nocturnal, Peripheral arterial tonometry, Phosphodiesterases, Psychosocial assessments, Tolerability, Treatment outcome",

author = "Hartmut Porst and Brock, {Gerald B.} and Krzysztof Kula and Ignacio Moncada and Francesco Montorsi and Basson, {Bruce R.} and Kraig Kinchen and Antonio Aversa",

year = "2012",

doi = "10.2164/jandrol.111.015289",

language = "English",

volume = "33",

pages = "1305--1322",

journal = "Journal of Andrology",

issn = "0196-3635",

publisher = "American Society of Andrology Inc.",

number = "6",

}

TY - JOUR

T1 - Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

AU - Porst, Hartmut

AU - Brock, Gerald B.

AU - Kula, Krzysztof

AU - Moncada, Ignacio

AU - Montorsi, Francesco

AU - Basson, Bruce R.

AU - Kinchen, Kraig

AU - Aversa, Antonio

PY - 2012

Y1 - 2012

N2 - Previous studies established the efficacy of oncedaily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5mg (with possible down-titration to 2.5mg; n=146) or placebo (n=69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21.7% on placebo; P

AB - Previous studies established the efficacy of oncedaily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5mg (with possible down-titration to 2.5mg; n=146) or placebo (n=69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21.7% on placebo; P

KW - Drug therapy

KW - Efficacy

KW - Endothelium

KW - Erection

KW - Morning

KW - Nocturnal

KW - Peripheral arterial tonometry

KW - Phosphodiesterases

KW - Psychosocial assessments

KW - Tolerability

KW - Treatment outcome

UR - http://www.scopus.com/inward/record.url?scp=84874405267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874405267&partnerID=8YFLogxK

U2 - 10.2164/jandrol.111.015289

DO - 10.2164/jandrol.111.015289

M3 - Article

C2 - 22790642

AN - SCOPUS:84874405267

VL - 33

SP - 1305

EP - 1322

JO - Journal of Andrology

JF - Journal of Andrology

SN - 0196-3635

IS - 6

ER -

Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this