Effects of osmoprotection on symptoms, ocular surface damage, and tear film modifications caused by glaucoma therapy

Gaspare Monaco, Viviana Cacioppo, Dario Consonni, Pasquale Troiano

Research output: Contribution to journalArticle

Abstract

Purpose. To determine the effects of 2 artificial tear formulas on the ocular surface in patients with glaucoma using topical preserved beta-blockers (BB) or prostaglandins (PG).Methods. This was a prospective, comparative, randomized, double-blind study with a crossover design. Twenty patients with dry eye were divided into 2 groups based on glaucoma treatment: BB (10 subjects) or PG (10 subjects). Each group was administered a 4-week course of unpreserved isotonic (300 mOsm/L) solution containing 0.2% sodium hyaluronate (SH) or a preserved isotonic (295-305 mOsm/L) solution containing 0.5% carboxymethylcellulose and 0.9% glycerin as compatible solute (CMCs) administered QID. After a 2-week washout period, the course of treatment was reversed. The primary efficacy criteria consisted of assessing symptoms according to the Ocular Surface Disease Index© (OSDI); the secondary efficacy criteria consisted of evaluating tear film confocal microscopy, central corneal thickness (CCT), and lissamine corneal and conjunctival staining (Oxford Grading System Score [OGSS]). Results. Within each group, only CMCs induced a significant improvement in OSDI and OGSS compared to baseline values: OSDI -20.5, p

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalEuropean Journal of Ophthalmology
Volume21
Issue number3
DOIs
Publication statusPublished - May 2011

Keywords

  • Compatible solute
  • Confocal microscopy
  • Glaucoma
  • Ocular surface
  • Optive osmoprotection

ASJC Scopus subject areas

  • Ophthalmology

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