Effects of oxiracetam, physostigmine, and their combination on active and passive avoidance learning in mice

Mario Sansone, Claudio Castellano, Sergio Palazzesi, Mario Battaglia, Martine Ammassari-Teule

Research output: Contribution to journalArticle


The nootropic drug oxiracetam (50 and 100 mg/kg) had no effect on one-trial passive avoidance acquisition in CD-1 mice, while the acetylcholinesterase inhibitor physostigmine improved passive avoidance performance at doses of 0.025 and 0.05 mg/kg given either pre- or posttraining. In a multitrial avoidance task (shuttle-box), a consistent tendency to better performance was displayed by mice receiving oxiracetam (50 and 100 mg/kg) or physostigmine (0.01 and 0.025 mg/kg, but not 0.05 mg/kg). Combinations of the two drugs never improved active or passive avoidance performance more than drugs given separately. This indicates no advantage in combining nootropics and anticholinesterase inhibitors to improve learning and memory.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number2
Publication statusPublished - 1993



  • Avoidance learning
  • Mice
  • Oxiracetam
  • Physostigmine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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