Effects of oxiracetam-scopolamine combinations on shuttle-box avoidance acquisition in mice

M. Sansone, V. Libri, F. Pavone, M. Ammassari-Teule

Research output: Contribution to journalArticlepeer-review

Abstract

The nootropic drug oxiracetam and the anticholinergic agent scopolamine were tested, alone or in combination, on shuttle-box avoidance acquisition and locomotor activity in mice of the CD-1 strain. Both drugs, given separately, slightly but significantly enhanced avoidance performance, but only scopolamine increased locomotor activity. Combinations of the 2 drugs, in some instances, enhanced avoidance performance more than drugs given separately, but the disinhibitory property of scopolamine makes it difficult to understand the role played by cholinergic mechanisms in these effects.

Original languageEnglish
Pages (from-to)208-216
Number of pages9
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume291
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology

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