Effects of particulate matter exposure on multiple sclerosis hospital admission in Lombardy region, Italy

Angelici Laura, Piola Mirko, Cavalleri Tommaso, Randi Giorgia, Cortini Francesca, Bergamaschi Roberto, Baccarelli A. Andrea, Bertazzi Pier Alberto, Pesatori Angela Cecilia, Bollati Valentina

Research output: Contribution to journalArticlepeer-review


Background: Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system, characterized by recurrent relapses of inflammation that cause mild to severe disability. Exposure to airborne particulate matter (PM) has been associated with acute increases in systemic inflammatory responses and neuroinflammation. In the present study, we hypothesize that exposure to PM <10 μm in diameter (PM10) might increase the occurrence of MS-related hospitalizations. Methods: We obtained daily concentrations of PM10 from 53 monitoring sites covering the study area and we identified 8287 MS-related hospitalization through hospital admission-discharge records of the Lombardy region, Italy, between 2001 and 2009. We used a Poisson regression analysis to investigate the association between exposure to PM10 and risk of hospitalization. Results: A higher RR of hospital admission for MS relapse was associated with exposure to PM10 at different time intervals. The maximum effect of PM10 on MS hospitalization was found for exposure between days 0 and 7: Hospital admission for MS increased 42% (95%CI 1.39-1.45) on the days preceded by one week with PM10 levels in the highest quartile. The p-value for trend across quartiles was

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalEnvironmental Research
Publication statusPublished - Feb 1 2016


  • Air pollution
  • Lombardy region
  • MS hospitalization
  • Multiple Sclerosis
  • PM

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry


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