Effects of Pathological Respiratory Pattern on Heart Rate Turbulence in Sleep Apnea

Giovanni D'Addio, Alberto De Felice, Giuseppe Insalaco, Maria Romano, Mario Cesarelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of partial or complete upper-airway obstruction during sleep. Although cardiac autonomic impairment is involved in the development of cardiovascular disease in OSAS, the mechanism underlying this derangement is rather unknown. It can be assessed by a recently introduced analysis of the heart rate turbulence (HRT). The aim of the paper is to describe the effects of pathological respiratory pattern on HRT in OSAS. HRT has been assessed by turbulence onset (TO) and turbulence slope (TS) indexes in 20 polysomnographic recordings of severe OSAS patients, and separately calculated during both normal (NR) and obstructive apnea (OA) respiratory pattern. Results showed that, although there is an overall depressed HRT for both indexes, while the TO during OA phases is not significantly different from those of NR epochs, the TS during OA phases is very significantly higher than in NR phases. This novel finding shows a previously unknown paradoxical increase of TS during OA episodes, followed by a marked decrease during subsequent NR phases, where OSAS patient show higher sympathetic tone. Such deeper understanding of the integrated autonomic response in different OSAS pathophysiological conditions could be useful to address an overall cardiorespiratory assessment and treatment in sleep-related breathing disorders.

Original languageEnglish
Title of host publicationStudies in Health Technology and Informatics
PublisherIOS Press
Pages506-510
Number of pages5
Volume205
ISBN (Print)9781614994312
DOIs
Publication statusPublished - 2014
Event25th European Medical Informatics Conference, MIE 2014 - Istanbul, Turkey
Duration: Aug 31 2014Sep 3 2014

Publication series

NameStudies in Health Technology and Informatics
Volume205
ISSN (Print)09269630
ISSN (Electronic)18798365

Other

Other25th European Medical Informatics Conference, MIE 2014
CountryTurkey
CityIstanbul
Period8/31/149/3/14

Fingerprint

Sleep Apnea Syndromes
Obstructive Sleep Apnea
Turbulence
Heart Rate
Apnea
Sleep
Airway Obstruction
Respiration
Cardiovascular Diseases

Keywords

  • Baroreflex sensitivity
  • Heart rate turbulence
  • Sleep-Apnea

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management
  • Medicine(all)

Cite this

D'Addio, G., De Felice, A., Insalaco, G., Romano, M., & Cesarelli, M. (2014). Effects of Pathological Respiratory Pattern on Heart Rate Turbulence in Sleep Apnea. In Studies in Health Technology and Informatics (Vol. 205, pp. 506-510). (Studies in Health Technology and Informatics; Vol. 205). IOS Press. https://doi.org/10.3233/978-1-61499-432-9-506

Effects of Pathological Respiratory Pattern on Heart Rate Turbulence in Sleep Apnea. / D'Addio, Giovanni; De Felice, Alberto; Insalaco, Giuseppe; Romano, Maria; Cesarelli, Mario.

Studies in Health Technology and Informatics. Vol. 205 IOS Press, 2014. p. 506-510 (Studies in Health Technology and Informatics; Vol. 205).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

D'Addio, G, De Felice, A, Insalaco, G, Romano, M & Cesarelli, M 2014, Effects of Pathological Respiratory Pattern on Heart Rate Turbulence in Sleep Apnea. in Studies in Health Technology and Informatics. vol. 205, Studies in Health Technology and Informatics, vol. 205, IOS Press, pp. 506-510, 25th European Medical Informatics Conference, MIE 2014, Istanbul, Turkey, 8/31/14. https://doi.org/10.3233/978-1-61499-432-9-506
D'Addio G, De Felice A, Insalaco G, Romano M, Cesarelli M. Effects of Pathological Respiratory Pattern on Heart Rate Turbulence in Sleep Apnea. In Studies in Health Technology and Informatics. Vol. 205. IOS Press. 2014. p. 506-510. (Studies in Health Technology and Informatics). https://doi.org/10.3233/978-1-61499-432-9-506
D'Addio, Giovanni ; De Felice, Alberto ; Insalaco, Giuseppe ; Romano, Maria ; Cesarelli, Mario. / Effects of Pathological Respiratory Pattern on Heart Rate Turbulence in Sleep Apnea. Studies in Health Technology and Informatics. Vol. 205 IOS Press, 2014. pp. 506-510 (Studies in Health Technology and Informatics).
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