Effects of pentoxifylline on inflammatory markers and blood pressure: a systematic review and meta-analysis of randomized controlled trials

Daniel Brie, Amirhossein Sahebkar, Peter E. Penson, Madalina Dinca, Sorin Ursoniu, Maria Corina Serban, Alberto Zanchetti, George Howard, Ali Ahmed, Wilbert S. Aronow, Paul Muntner, Gregory Y H Lip, Nathan D. Wong, Jacek Rysz, Maciej Banach

Research output: Contribution to journalArticle

Abstract

INTRODUCTION:: Pentoxifylline is a xanthine derivative with potential cardiovascular benefits. AIM:: To evaluate the impact of pentoxifylline on blood pressure (BP) and plasma TNF-α, C-reactive protein (CRP) and IL-6 through a systematic review and meta-analysis of randomized controlled trials. METHODS:: The protocol was registered (PROSPERO: CRD42016035988). The search included PUBMED, ProQuest, Scopus and EMBASE until 1 September 2015 to identify trials reporting BP or inflammatory markers during pentoxifylline therapy. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WDF) and 95% confidence intervals (CIs) as summary statistics. RESULTS:: Fifteen studies (16 treatment arms) were found to be eligible for inclusion. Meta-analysis did not suggest any effect of pentoxifylline on either SBP or DBP. Pentoxifylline treatment was associated with a significant reduction in plasma concentrations of TNF-α (WDF: −1.03?pg/ml, 95% CI: −1.54, −0.51; P?<?0.001, 11 treatment arms) and CRP (WDF: −1.39?mg/l, 95% CI: −2.68, −0.10; P?=?0.034, five treatment arms). No alteration in plasma IL-6 concentration was observed. The impact of pentoxifylline on plasma TNF-α levels was found to be positively associated with treatment duration (slope: 0.031; 95% CI: 0.004, 0.057; P?=?0.023) but independent of pentoxifylline dose (slope: −0.0003; 95% CI: −0.002, 0.001; P?=?0.687). CONCLUSION:: Pentoxifylline did not alter BP or plasma IL-6 concentration, but significantly reduced circulating TNF-α and CRP concentrations.

Original languageEnglish
JournalJournal of Hypertension
DOIs
Publication statusAccepted/In press - Aug 10 2016

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

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    Brie, D., Sahebkar, A., Penson, P. E., Dinca, M., Ursoniu, S., Serban, M. C., Zanchetti, A., Howard, G., Ahmed, A., Aronow, W. S., Muntner, P., Lip, G. Y. H., Wong, N. D., Rysz, J., & Banach, M. (Accepted/In press). Effects of pentoxifylline on inflammatory markers and blood pressure: a systematic review and meta-analysis of randomized controlled trials. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000001086