Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up

A. Sansone, D. A. Fegatelli, C. Pozza, G. Fattorini, R. Lauretta, M. Minnetti, F. Romanelli, P. Lucatelli, M. Corona, M. Bezzi, F. Lombardo, A. Lenzi, D. Gianfrilli

Research output: Contribution to journalArticle

Abstract

Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (/=20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean+/-s.d.: 14.5 +/- 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean+/-s.d.: 15.7 +/- 3.8 ml; P = 0.032). Repeated measures mixed models showed a significant interaction between LTH and time posttreatment when correcting for baseline left testicular volume (beta = 0.114, 95% confidence interval [CI]: 0.018-0.210, P = 0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% CI: 0.221-2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% CI: -0.135--0.009; P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implications of these findings need to be confirmed in longer and larger prospective studies.
Original languageEnglish
JournalAsian Journal of Andrology
DOIs
Publication statusPublished - Dec 25 2018
Externally publishedYes

Fingerprint

Varicocele
Confidence Intervals
Young Adult
Growth
Databases
Prospective Studies
Psychology
Therapeutics

Keywords

  • catch-up growth
  • percutaneous treatment
  • testicular hypotrophy
  • testicular ultrasound
  • testicular volume
  • varicocele
  • young adults

Cite this

Sansone, A., Fegatelli, D. A., Pozza, C., Fattorini, G., Lauretta, R., Minnetti, M., ... Gianfrilli, D. (2018). Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up. Asian Journal of Andrology. https://doi.org/10.4103/aja.aja_102_18 [doi]

Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up. / Sansone, A.; Fegatelli, D. A.; Pozza, C.; Fattorini, G.; Lauretta, R.; Minnetti, M.; Romanelli, F.; Lucatelli, P.; Corona, M.; Bezzi, M.; Lombardo, F.; Lenzi, A.; Gianfrilli, D.

In: Asian Journal of Andrology, 25.12.2018.

Research output: Contribution to journalArticle

Sansone, A, Fegatelli, DA, Pozza, C, Fattorini, G, Lauretta, R, Minnetti, M, Romanelli, F, Lucatelli, P, Corona, M, Bezzi, M, Lombardo, F, Lenzi, A & Gianfrilli, D 2018, 'Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up', Asian Journal of Andrology. https://doi.org/10.4103/aja.aja_102_18 [doi]
Sansone, A. ; Fegatelli, D. A. ; Pozza, C. ; Fattorini, G. ; Lauretta, R. ; Minnetti, M. ; Romanelli, F. ; Lucatelli, P. ; Corona, M. ; Bezzi, M. ; Lombardo, F. ; Lenzi, A. ; Gianfrilli, D. / Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up. In: Asian Journal of Andrology. 2018.
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abstract = "Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular {"}catch-up growth{"} in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (/=20{\%} difference between left and right testicular volume at baseline, was observed in 26 (22.8{\%}) men. Participants with LTH (mean+/-s.d.: 14.5 +/- 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean+/-s.d.: 15.7 +/- 3.8 ml; P = 0.032). Repeated measures mixed models showed a significant interaction between LTH and time posttreatment when correcting for baseline left testicular volume (beta = 0.114, 95{\%} confidence interval [CI]: 0.018-0.210, P = 0.020), resulting in a catch-up growth of up to 1.37 ml per year (95{\%} CI: 0.221-2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95{\%} CI: -0.135--0.009; P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implications of these findings need to be confirmed in longer and larger prospective studies.",
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AU - Pozza, C.

AU - Fattorini, G.

AU - Lauretta, R.

AU - Minnetti, M.

AU - Romanelli, F.

AU - Lucatelli, P.

AU - Corona, M.

AU - Bezzi, M.

AU - Lombardo, F.

AU - Lenzi, A.

AU - Gianfrilli, D.

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N2 - Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (/=20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean+/-s.d.: 14.5 +/- 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean+/-s.d.: 15.7 +/- 3.8 ml; P = 0.032). Repeated measures mixed models showed a significant interaction between LTH and time posttreatment when correcting for baseline left testicular volume (beta = 0.114, 95% confidence interval [CI]: 0.018-0.210, P = 0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% CI: 0.221-2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% CI: -0.135--0.009; P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implications of these findings need to be confirmed in longer and larger prospective studies.

AB - Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (/=20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean+/-s.d.: 14.5 +/- 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean+/-s.d.: 15.7 +/- 3.8 ml; P = 0.032). Repeated measures mixed models showed a significant interaction between LTH and time posttreatment when correcting for baseline left testicular volume (beta = 0.114, 95% confidence interval [CI]: 0.018-0.210, P = 0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% CI: 0.221-2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% CI: -0.135--0.009; P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implications of these findings need to be confirmed in longer and larger prospective studies.

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KW - percutaneous treatment

KW - testicular hypotrophy

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JO - Asian Journal of Andrology

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