Effects of pharmacological agents, sleep deprivation, Hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer's disease

Claudio Babiloni, Francesco Infarinato, Fabienne Aujard, Jesper Frank Bastlund, Marina Bentivoglio, Giuseppe Bertini, Claudio Del Percio, Paolo Francesco Fabene, GianLuigi Forloni, Maria Trinidad Herrero Ezquerro, Francesco Mattia Noè, Fabien Pifferi, Francisco Ros-Bernal, Ditte Zerlang Christensen, Sophie Dix, Jill C. Richardson, Yves Lamberty, Wilhelmus Drinkenburg, Paolo Maria Rossini

Research output: Contribution to journalArticle

Abstract

Different kinds of challenge can alter spontaneous ongoing electroencephalographic (EEG) rhythms in animal models, thus providing paradigms to evaluate treatment effects in drug discovery. The effects of challenges represented by pharmacological agents, hypoxia, sleep deprivation and transcranial magnetic stimulation (TMS) on EEG rhythms are here reviewed to build a knowledge platform for innovative translational models for drug discovery in Alzheimer's disease (AD). It has been reported that antagonists of cholinergic neurotransmission cause synchronisation of spontaneous ongoing EEG rhythms in terms of enhanced power of EEG low frequencies and decreased power of EEG high frequencies. Acetylcholinesterase inhibitors and serotonergic drugs may restore a normal pattern of EEG desynchronisation. Sleep deprivation and hypoxia challenges have also been reported to elicit abnormal synchronisation of spontaneous ongoing EEG rhythms in rodents. The feasibility and reproducibility of TMS have been demonstrated in rodents but information on a consistent modulation of EEG after TMS manipulation is very limited. Transgenic mice over-expressing human amyloid precursor protein complementary DNAs (cDNAs) harbouring the 'Swedish' mutation and PS-1 cDNAs harbouring the A264E mutation, which recapitulate some of the pathological features of AD, exhibit alterations of spontaneous ongoing EEG rhythms at several low and high frequencies. This does not appear, however, to be a consequence of beta-amyloid deposition in the brain. The present review provides a critical evaluation of changes of spontaneous ongoing EEG rhythms due to the experimental manipulations described above, in order to stimulate the promote more adherent models fitting dynamics in humans.

Original languageEnglish
Pages (from-to)437-451
Number of pages15
JournalClinical Neurophysiology
Volume124
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Animal models
  • Drug treatments
  • EEG
  • Electroencephalography
  • Neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

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  • Cite this

    Babiloni, C., Infarinato, F., Aujard, F., Bastlund, J. F., Bentivoglio, M., Bertini, G., Del Percio, C., Fabene, P. F., Forloni, G., Herrero Ezquerro, M. T., Noè, F. M., Pifferi, F., Ros-Bernal, F., Christensen, D. Z., Dix, S., Richardson, J. C., Lamberty, Y., Drinkenburg, W., & Rossini, P. M. (2013). Effects of pharmacological agents, sleep deprivation, Hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer's disease. Clinical Neurophysiology, 124(3), 437-451. https://doi.org/10.1016/j.clinph.2012.07.023