Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver

Giacomo Manenti, Tommaso A. Dragani, Giuseppe Della Porta

Research output: Contribution to journalArticlepeer-review

Abstract

The promoters of murine hepatocarcinogenesis phenobarbital (PB) and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) given to adult C3Hf female mice increased the content of total liver DNA by 1.6-1.8-fold each week after the beginning of treatment. Both compounds increased the aminopyrine-N-demethylase activity, decreased the glucose 6-phosphatase (G6Pase), alkaline phosphodiesterase I and alkaline phosphatase specific activities, but did not modify the γ-glutamyltransferase levels. Both compounds decreased the abundance of tyrosine aminotransferase- and metallothionein I-related RNA transcripts. These findings confirmed the PB-like activity of TCPOBOP and showed that both chemicals had a pleiotropic effect on mouse liver, that was not limited to stimulation of drug metabolism, but also affected other hepatocyte functions.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalChemico-Biological Interactions
Volume64
Issue number1-2
DOIs
Publication statusPublished - 1987

Keywords

  • 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
  • Differentiation
  • Phenobarbital
  • Tumor promoter

ASJC Scopus subject areas

  • Toxicology

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