Effects of phenobarbitone on the distribution, metabolism and biliary excretion of erythromycin in rats

L. Manzo, C. Gregotti, P. Richelmi, A. Di Nucci, F. Bertè

Research output: Contribution to journalArticlepeer-review

Abstract

The administration of phenobarbitone to the rat (8 mg/100 g BW) once daily for 3 days significantly decreased the serum and tissue levels of erythromycin administered intraperitoneally (5 mg/100 g BW). Furthermore, phenobarbitone stimulated the hepatic microsomal N-demethylation of erythromycin and increased the biliary concentration and the biliary excretion rate of the unmetabolized antibiotic. These effects were accompanied by augmented liver mass and bile flow. The possibility is discussed that erythromycin concentrates in the bile through a specialized hepatic drug transport system, activated by phenobarbitone.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalChemotherapy
Volume26
Issue number3
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Pharmacology (medical)

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