Effects of phosphorylcholine coating on extracorporeal circulation management and postoperative outcome: A double-blind randomized study

Roberto Lorusso, Giuseppe De Cicco, Pasquale Totaro, Sandro Gelsomino

Research output: Contribution to journalArticle

Abstract

The aim of the study was to evaluate the effects of phosphorylcholine coating (PC) on intra-operative extracorporeal circulation (ECC) management and perioperative outcome. One hundred and twenty consecutive cardiac surgery patients were enrolled for the study. Patients were randomly assigned to ECC with PC circuits (60 patients) or to corresponding non-coated circuits (60 patients). Transoxygenator pressure drop, blood flows, flow resistances and ECC parameters were recorded at surgery before ECC institution and every 10 min thereafter until ECC discontinuation. Postoperative variables (hematological parameters, drainage blood loss, mechanical ventilation time, incidence of atrial fibrillation, use of blood products) were also assessed and compared between groups. No differences were found between the two groups in terms of demographics, operative, and hematological profiles. PC showed, at equal pump flows, to significantly (P

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalInteractive Cardiovascular and Thoracic Surgery
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Artificial surface coating
  • Cardiac surgery
  • Extracorporeal circulation
  • Phosphorylcholine coating
  • Platelet consumption

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

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