Abstract
I.p. administration of piribedil methansulphonate to male Sprague-Dawley rats resulted in a remarkable increase of brain MOPEG-SO4 which was consistent over time. In parallel experiments brain content of NA was found significantly reduced 30 and 60 min after drug administration. The effect seems to be dose dependent. These data cast some doubts on the relative specificity of action of piribedil as a dopaminergic activator.
| Original language | English |
|---|---|
| Pages (from-to) | 214-216 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1974 |
Fingerprint
Keywords
- MOPEG-SO
- Noradrenaline
- Piribedil
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Effects of piribedil on noradrenaline and MOPEG-SO4 levels in the rat brain. / Garattini, Silvio; Bareggi, Silvio R.; Marc, Viviana; Calderini, Gabriella; Morselli, Paolo L.
In: European Journal of Pharmacology, Vol. 28, No. 1, 1974, p. 214-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of piribedil on noradrenaline and MOPEG-SO4 levels in the rat brain
AU - Garattini, Silvio
AU - Bareggi, Silvio R.
AU - Marc, Viviana
AU - Calderini, Gabriella
AU - Morselli, Paolo L.
PY - 1974
Y1 - 1974
N2 - I.p. administration of piribedil methansulphonate to male Sprague-Dawley rats resulted in a remarkable increase of brain MOPEG-SO4 which was consistent over time. In parallel experiments brain content of NA was found significantly reduced 30 and 60 min after drug administration. The effect seems to be dose dependent. These data cast some doubts on the relative specificity of action of piribedil as a dopaminergic activator.
AB - I.p. administration of piribedil methansulphonate to male Sprague-Dawley rats resulted in a remarkable increase of brain MOPEG-SO4 which was consistent over time. In parallel experiments brain content of NA was found significantly reduced 30 and 60 min after drug administration. The effect seems to be dose dependent. These data cast some doubts on the relative specificity of action of piribedil as a dopaminergic activator.
KW - MOPEG-SO
KW - Noradrenaline
KW - Piribedil
UR - http://www.scopus.com/inward/record.url?scp=0016204127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016204127&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(74)90134-4
DO - 10.1016/0014-2999(74)90134-4
M3 - Article
C2 - 4430323
AN - SCOPUS:0016204127
VL - 28
SP - 214
EP - 216
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -