Effects of piribedil on noradrenaline and MOPEG-SO4 levels in the rat brain

Silvio Garattini, Silvio R. Bareggi, Viviana Marc, Gabriella Calderini, Paolo L. Morselli

Research output: Contribution to journalArticlepeer-review

Abstract

I.p. administration of piribedil methansulphonate to male Sprague-Dawley rats resulted in a remarkable increase of brain MOPEG-SO4 which was consistent over time. In parallel experiments brain content of NA was found significantly reduced 30 and 60 min after drug administration. The effect seems to be dose dependent. These data cast some doubts on the relative specificity of action of piribedil as a dopaminergic activator.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalEuropean Journal of Pharmacology
Volume28
Issue number1
DOIs
Publication statusPublished - 1974

Keywords

  • MOPEG-SO
  • Noradrenaline
  • Piribedil

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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