Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action

Rossella Fioravanti, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, Leonardo Mattiello, Ettore Novellino, Paola Checconi, Anna Teresa Palamara, Lucia Nencioni, Roberto Di Santo

Research output: Contribution to journalArticle

Abstract

A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.

Original languageEnglish
Pages (from-to)5046-5052
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume20
Issue number16
DOIs
Publication statusPublished - Aug 15 2012

Keywords

  • Antivirals
  • Curcumin
  • Influenza
  • Polyphenols
  • Resveratrol

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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  • Cite this

    Fioravanti, R., Celestino, I., Costi, R., Cuzzucoli Crucitti, G., Pescatori, L., Mattiello, L., Novellino, E., Checconi, P., Palamara, A. T., Nencioni, L., & Santo, R. D. (2012). Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. Bioorganic and Medicinal Chemistry, 20(16), 5046-5052. https://doi.org/10.1016/j.bmc.2012.05.062