Effects of postmenopausal hypoestrogenism on skin collagen

Pietro Affinito, Stefano Palomba, Claudia Sorrentino, Costantino Di Carlo, Giuseppe Bifulco, Maria Paola Arienzo, Carmine Nappi

Research output: Contribution to journalArticle

Abstract

Objective: The aim of our study was to evaluate the effect of aging and postmenopausal hypoestrogenism on skin collagen content. Methods: Thirty-two women (mean age 48.78 ± 9.86; year ± S.D., range 28-68), 14 in premenopause and 18 in postmenopause, underwent skin biopsies performed during laparotomic operation. The amount of collagen type I, III and type III/type I ratio was evaluated by immunohistochemistry and computerised image analysis, and was related to age and years of postmenopause. Results: In the postmenopausal patients, a significant (P <0.01) decrease of percentage of skin collagen type I, type III and type III/type I ratio was observed in comparison to premenopausal women. The percentages of collagen type I, type III and type III/I ratio of all patients studied was significantly (P <0.01) correlated with chronological age (r = 0.88, 0.89 and 0.61, respectively). Considering only postmenopausal subjects, the correlation with chronological age was significant (P <0.01) for collagen type I and type III of postmenopausal women (r = 0.59, r = 0.64, respectively), but not for the type III/I ratio (r = 0.37, P = 0.131). The percentages of collagen type I, type III and type III/I ratio of postmenopausal women showed a significant (P <0.01) inverse correlation with years of postmenopause (r = 0.76, 0.73 and 0.73, respectively). Conclusions: Our data suggest that the decrease of skin collagen is an estrogen-related phenomenon.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalMaturitas
Volume33
Issue number3
DOIs
Publication statusPublished - Dec 15 1999

Fingerprint

Collagen Type I
Skin
Postmenopause
Collagen
Premenopause
Collagen Type III
Biopsy
Image analysis
Estrogens
Aging of materials
Immunohistochemistry

Keywords

  • Collagen
  • Hypoestrogenism
  • Menopause
  • Sex hormones
  • Skin

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

Cite this

Affinito, P., Palomba, S., Sorrentino, C., Di Carlo, C., Bifulco, G., Arienzo, M. P., & Nappi, C. (1999). Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas, 33(3), 239-247. https://doi.org/10.1016/S0378-5122(99)00077-8

Effects of postmenopausal hypoestrogenism on skin collagen. / Affinito, Pietro; Palomba, Stefano; Sorrentino, Claudia; Di Carlo, Costantino; Bifulco, Giuseppe; Arienzo, Maria Paola; Nappi, Carmine.

In: Maturitas, Vol. 33, No. 3, 15.12.1999, p. 239-247.

Research output: Contribution to journalArticle

Affinito, P, Palomba, S, Sorrentino, C, Di Carlo, C, Bifulco, G, Arienzo, MP & Nappi, C 1999, 'Effects of postmenopausal hypoestrogenism on skin collagen', Maturitas, vol. 33, no. 3, pp. 239-247. https://doi.org/10.1016/S0378-5122(99)00077-8
Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP et al. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas. 1999 Dec 15;33(3):239-247. https://doi.org/10.1016/S0378-5122(99)00077-8
Affinito, Pietro ; Palomba, Stefano ; Sorrentino, Claudia ; Di Carlo, Costantino ; Bifulco, Giuseppe ; Arienzo, Maria Paola ; Nappi, Carmine. / Effects of postmenopausal hypoestrogenism on skin collagen. In: Maturitas. 1999 ; Vol. 33, No. 3. pp. 239-247.
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