Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes

Antonio Ceriello, Ludovica Piconi, Lisa Quagliaro, Yan Wang, Catherine A. Schnabel, James A. Ruggles, Maurice A. Cluster, David G. Maggs, Christian Weyer

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - Oxidative stress has been shown to be increased in the postprandial period in patients with diabetes and has been implicated in the pathogenesis of micro- and macrovascular complications. The aim of this post hoc analysis was to assess the effects of pramlintide, an amylin analog shown to reduce postprandial glucose excursions in patients with diabetes, on markers of oxidative stress in the postprandial period. RESEARCH DESIGN AND METHODS - In a randomized, single-blind, placebo-controlled, crossover study, 18 evaluable subjects with type 1 diabetes underwent two standardized breakfast meal tests and received pramlintide or placebo in addition to their preprandial insulin. The plasma concentrations of glucose and markers of oxidative stress (nitrotyrosine, oxidized LDL [ox-LDL], and total radical-trapping antioxidant parameter [TRAP]) were measured at baseline and during the 4-h postprandial period. RESULTS - Compared with placebo, pramlintide treatment significantly reduced postprandial excursions of glucose, nitrotyrosine, and ox-LDL and prevented a decline in TRAP (P <0.03 for all comparisons). Correlation analyses adjusted for treatment revealed a significant association between postprandial mean incremental area under the curve from 0 to 4 h (AUC 0-4 h) for glucose and postprandial mean incremental AUC 0-4 h for each measure of oxidative stress (r = 0.75, 0.54, and -0.63 for nitrotyrosine, ox-LDL, and TRAP, respectively; P <0.001 for all correlations). CONCLUSIONS - These findings indicate that the postprandial glucose-lowering effect of pramlintide in type 1 diabetes is associated with a significant reduction in postprandial oxidative stress.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalDiabetes Care
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2005

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes'. Together they form a unique fingerprint.

  • Cite this

    Ceriello, A., Piconi, L., Quagliaro, L., Wang, Y., Schnabel, C. A., Ruggles, J. A., Cluster, M. A., Maggs, D. G., & Weyer, C. (2005). Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes. Diabetes Care, 28(3), 632-637. https://doi.org/10.2337/diacare.28.3.632