Effects of pre-dialysis resistance training on sarcopenia, inflammatory profile, and anemia biomarkers in older community-dwelling patients with chronic kidney disease: a randomized controlled trial

André Bonadias Gadelha, Matteo Cesari, Hugo Luca Corrêa, Rodrigo Vanerson Passos Neves, Caio Victor Sousa, Lysleine Alves Deus, Michel Kendy Souza, Andrea Lucena Reis, Milton Rocha Moraes, Jonato Prestes, Herbert Gustavo Simões, Rosangela Vieira Andrade, Gislane Ferreira Melo, Thiago Santos Rosa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Sarcopenia and chronic kidney disease (CKD) have been associated with negative outcomes in older people, including inflammatory profile and anemia biomarkers. Aims: To investigate the effects of pre-dialysis resistance training (RT) on sarcopenia, inflammatory profile, and anemia biomarkers in older patients with CKD. Methods: A total of 107 patients with CKD (65.4 ± 3.7 years) were randomly allocated into four groups: sarcopenic RT (n = 37), non-sarcopenic RT (n = 20), sarcopenic control (n = 28), and non-sarcopenic control (n = 22). DXA and handgrip strength were used to classify sarcopenia according to EWGSOP-2. Treatment groups underwent a 24-week intervention with RT before each dialysis session, three times per week. Blood sample analysis for ferritin, hepcidin, iron availability, and inflammatory profile (TNFα, IL-6, and IL-10) was conducted. All-cause mortality was recorded over 5 years. Results: Sarcopenic RT group increased iron availability after the intervention, while their counterparts decreased. Ferritin and hepcidin significantly decreased in sarcopenic RT group. RT elicited a reduction in both TNFα and IL-6, while increasing IL-10 in both intervention groups. The rate of sarcopenic subjects substantially decreased after the intervention period (from 37 to 17 in the RT group; p = 0.01). The proportion of deaths was higher (P = 0.033) for sarcopenic subjects (Controls 35.7% vs RT 29.7%) when compared to non-sarcopenic subjects (Controls 18% vs RT 10%). The proportion of deaths decreased according to the randomization group (X2 = 8.704; P < 0.1). Conclusions: The 24-week RT intervention elicited a better sarcopenia status, better inflammatory profile, and improved anemia biomarkers. Sarcopenia was associated with higher mortality rate in older patients with CKD.

Original languageEnglish
JournalInternational Urology and Nephrology
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Aging
  • Chronic kidney disease
  • Inflammatory profile
  • Mortality
  • Muscle strength

ASJC Scopus subject areas

  • Nephrology
  • Urology

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