Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates

Costantino Romagnoli, Maria Pia De Carolis, Patrizia Papacci, Valentina Polimeni, Rita Luciano, Fiammetta Piersigilli, Angelica Bibiana Delogu, Giuseppe Tortorolo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: To evaluate the effects on cerebral and renal blood flow velocities of ibuprofen when used as prophylaxis for patent ductus arteriosus in preterm neonates (gestational age ≤30 weeks). Methods: Blood flow velocities in the anterior cerebral artery and the renal artery were measured with Doppler ultrasonography in 17 neonates before, during, and 10, 30, and 60 minutes after administration of 10 mg/kg ibuprofen lysine. Results: In four (23.6%) neonates without echocardiographic patency of the ductus, no significant modifications in blood flow velocities and Doppler indexes were found either in the anterior cerebral artery or in the renal artery. In 13 (76.4%) neonates, cardiac echocardiographic Doppler showed patency of the ductus and left-to-right shunt. In these neonates diastolic and mean blood velocities rapidly increased both in the anterior cerebral artery and the renal artery (P <.0001). Resistance and pulsatility index decreased during the study period (P <.0001 and P <.001, respectively, in the anterior cerebral artery; P <.0001 in the renal artery). Conclusions: Data suggest that ibuprofen does not determine any direct effect on cerebral and renal blood flow velocities; hemodynamic modifications observed in neonates with patency of ductus can be related to closure of the ductus induced by the drug.

Original languageEnglish
Pages (from-to)676-683
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume67
Issue number6
Publication statusPublished - 2000

Fingerprint

Anterior Cerebral Artery
Blood Flow Velocity
Ibuprofen
Renal Artery
Cerebrovascular Circulation
Hemodynamics
Kidney
Renal Circulation
Doppler Ultrasonography
Patent Ductus Arteriosus
Gestational Age
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Romagnoli, C., De Carolis, M. P., Papacci, P., Polimeni, V., Luciano, R., Piersigilli, F., ... Tortorolo, G. (2000). Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates. Clinical Pharmacology and Therapeutics, 67(6), 676-683.

Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates. / Romagnoli, Costantino; De Carolis, Maria Pia; Papacci, Patrizia; Polimeni, Valentina; Luciano, Rita; Piersigilli, Fiammetta; Delogu, Angelica Bibiana; Tortorolo, Giuseppe.

In: Clinical Pharmacology and Therapeutics, Vol. 67, No. 6, 2000, p. 676-683.

Research output: Contribution to journalArticle

Romagnoli, C, De Carolis, MP, Papacci, P, Polimeni, V, Luciano, R, Piersigilli, F, Delogu, AB & Tortorolo, G 2000, 'Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates', Clinical Pharmacology and Therapeutics, vol. 67, no. 6, pp. 676-683.
Romagnoli, Costantino ; De Carolis, Maria Pia ; Papacci, Patrizia ; Polimeni, Valentina ; Luciano, Rita ; Piersigilli, Fiammetta ; Delogu, Angelica Bibiana ; Tortorolo, Giuseppe. / Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates. In: Clinical Pharmacology and Therapeutics. 2000 ; Vol. 67, No. 6. pp. 676-683.
@article{1688adea89994c59bf39c6198402d050,
title = "Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates",
abstract = "Objective: To evaluate the effects on cerebral and renal blood flow velocities of ibuprofen when used as prophylaxis for patent ductus arteriosus in preterm neonates (gestational age ≤30 weeks). Methods: Blood flow velocities in the anterior cerebral artery and the renal artery were measured with Doppler ultrasonography in 17 neonates before, during, and 10, 30, and 60 minutes after administration of 10 mg/kg ibuprofen lysine. Results: In four (23.6{\%}) neonates without echocardiographic patency of the ductus, no significant modifications in blood flow velocities and Doppler indexes were found either in the anterior cerebral artery or in the renal artery. In 13 (76.4{\%}) neonates, cardiac echocardiographic Doppler showed patency of the ductus and left-to-right shunt. In these neonates diastolic and mean blood velocities rapidly increased both in the anterior cerebral artery and the renal artery (P <.0001). Resistance and pulsatility index decreased during the study period (P <.0001 and P <.001, respectively, in the anterior cerebral artery; P <.0001 in the renal artery). Conclusions: Data suggest that ibuprofen does not determine any direct effect on cerebral and renal blood flow velocities; hemodynamic modifications observed in neonates with patency of ductus can be related to closure of the ductus induced by the drug.",
author = "Costantino Romagnoli and {De Carolis}, {Maria Pia} and Patrizia Papacci and Valentina Polimeni and Rita Luciano and Fiammetta Piersigilli and Delogu, {Angelica Bibiana} and Giuseppe Tortorolo",
year = "2000",
language = "English",
volume = "67",
pages = "676--683",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates

AU - Romagnoli, Costantino

AU - De Carolis, Maria Pia

AU - Papacci, Patrizia

AU - Polimeni, Valentina

AU - Luciano, Rita

AU - Piersigilli, Fiammetta

AU - Delogu, Angelica Bibiana

AU - Tortorolo, Giuseppe

PY - 2000

Y1 - 2000

N2 - Objective: To evaluate the effects on cerebral and renal blood flow velocities of ibuprofen when used as prophylaxis for patent ductus arteriosus in preterm neonates (gestational age ≤30 weeks). Methods: Blood flow velocities in the anterior cerebral artery and the renal artery were measured with Doppler ultrasonography in 17 neonates before, during, and 10, 30, and 60 minutes after administration of 10 mg/kg ibuprofen lysine. Results: In four (23.6%) neonates without echocardiographic patency of the ductus, no significant modifications in blood flow velocities and Doppler indexes were found either in the anterior cerebral artery or in the renal artery. In 13 (76.4%) neonates, cardiac echocardiographic Doppler showed patency of the ductus and left-to-right shunt. In these neonates diastolic and mean blood velocities rapidly increased both in the anterior cerebral artery and the renal artery (P <.0001). Resistance and pulsatility index decreased during the study period (P <.0001 and P <.001, respectively, in the anterior cerebral artery; P <.0001 in the renal artery). Conclusions: Data suggest that ibuprofen does not determine any direct effect on cerebral and renal blood flow velocities; hemodynamic modifications observed in neonates with patency of ductus can be related to closure of the ductus induced by the drug.

AB - Objective: To evaluate the effects on cerebral and renal blood flow velocities of ibuprofen when used as prophylaxis for patent ductus arteriosus in preterm neonates (gestational age ≤30 weeks). Methods: Blood flow velocities in the anterior cerebral artery and the renal artery were measured with Doppler ultrasonography in 17 neonates before, during, and 10, 30, and 60 minutes after administration of 10 mg/kg ibuprofen lysine. Results: In four (23.6%) neonates without echocardiographic patency of the ductus, no significant modifications in blood flow velocities and Doppler indexes were found either in the anterior cerebral artery or in the renal artery. In 13 (76.4%) neonates, cardiac echocardiographic Doppler showed patency of the ductus and left-to-right shunt. In these neonates diastolic and mean blood velocities rapidly increased both in the anterior cerebral artery and the renal artery (P <.0001). Resistance and pulsatility index decreased during the study period (P <.0001 and P <.001, respectively, in the anterior cerebral artery; P <.0001 in the renal artery). Conclusions: Data suggest that ibuprofen does not determine any direct effect on cerebral and renal blood flow velocities; hemodynamic modifications observed in neonates with patency of ductus can be related to closure of the ductus induced by the drug.

UR - http://www.scopus.com/inward/record.url?scp=0034120037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034120037&partnerID=8YFLogxK

M3 - Article

VL - 67

SP - 676

EP - 683

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 6

ER -