Effects of propranolol in a case of orthostatic hypotension

G. Brevetti, M. Chiariello, G. Lavecchia, F. Rengo

Research output: Contribution to journalArticlepeer-review


In a hypertensive patient with orthostatic hypotension, the changes in several haemodynamic indices with respect to posture were evaluated. In the upright position, systemic blood pressure was reduced as compared with the supine position, and peripheral vasodilatation was present, as shown by an increase in Jantsch's index of the impedance plethysmographic tracings. Systolic time intervals remained unchanged with changes in posture. Propranolol 10 mg intravenously brought the response to normal. In fact, after beta-blockade in the standing position the blood pressure remained unchanged and normal peripheral vasoconstriction was observed. Similar results were seen during atrial pacing at a constant heart rate of 130 beats/minute. In this patient, propranolol appears to normalise the reponse to the posture change, by restoring normal vasoconstriction in the upright position.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalBritish Heart Journal
Issue number2
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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