Effects of propranolol on venous compliance in conscious rats with pre-hepatic portal hypertension

Victoria Andreu, Juan Carlos Garcia-Pagan, Raffaela Lionetti, Carlos Piera, Juan G. Abraldes, Jaume Bosch

Research output: Contribution to journalArticle

Abstract

Background/Aims: The venous system is the primary capacitance region in the body. However, the influence of active changes in the venous system on the hemodynamic alterations of portal hypertension is poorly understood. To investigate venous compliance (VC) in conscious partial portal vein ligated rats (PPVL) and the effect of propranolol on VC. Methods: Venous compliance was derived from the relationship between changes in mean circulatory filling pressure (MCFP) and changes in blood volume (BV). Measurements were performed before and after i.v. propranolol (7.5 mg/Kg) or placebo in rats with portal hypertension due to PPVL and sham operated controls. Results: PPVL rats had an increased VC when compared to Sham (4.9±1.4 vs. 3.7±0.9 ml kg-1 mmHg-1; P

Original languageEnglish
Pages (from-to)1040-1045
Number of pages6
JournalJournal of Hepatology
Volume44
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Conscious rats
  • Portal hypertension
  • Portal vein ligation
  • Propranolol
  • Venous compliance

ASJC Scopus subject areas

  • Gastroenterology

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