Abstract
Background/Aims: The venous system is the primary capacitance region in the body. However, the influence of active changes in the venous system on the hemodynamic alterations of portal hypertension is poorly understood. To investigate venous compliance (VC) in conscious partial portal vein ligated rats (PPVL) and the effect of propranolol on VC. Methods: Venous compliance was derived from the relationship between changes in mean circulatory filling pressure (MCFP) and changes in blood volume (BV). Measurements were performed before and after i.v. propranolol (7.5 mg/Kg) or placebo in rats with portal hypertension due to PPVL and sham operated controls. Results: PPVL rats had an increased VC when compared to Sham (4.9±1.4 vs. 3.7±0.9 ml kg-1 mmHg-1; P
Original language | English |
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Pages (from-to) | 1040-1045 |
Number of pages | 6 |
Journal | Journal of Hepatology |
Volume | 44 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2006 |
Keywords
- Conscious rats
- Portal hypertension
- Portal vein ligation
- Propranolol
- Venous compliance
ASJC Scopus subject areas
- Gastroenterology