Effects of propranolol on venous compliance in conscious rats with pre-hepatic portal hypertension

Victoria Andreu; Juan Carlos Garcia-Pagan; Raffaela Lionetti; Carlos Piera; Juan G. Abraldes; Jaume Bosch

doi:10.1016/j.jhep.2005.10.024

Effects of propranolol on venous compliance in conscious rats with pre-hepatic portal hypertension

Victoria Andreu, Juan Carlos Garcia-Pagan, Raffaela Lionetti, Carlos Piera, Juan G. Abraldes, Jaume Bosch

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article

Abstract

Background/Aims: The venous system is the primary capacitance region in the body. However, the influence of active changes in the venous system on the hemodynamic alterations of portal hypertension is poorly understood. To investigate venous compliance (VC) in conscious partial portal vein ligated rats (PPVL) and the effect of propranolol on VC. Methods: Venous compliance was derived from the relationship between changes in mean circulatory filling pressure (MCFP) and changes in blood volume (BV). Measurements were performed before and after i.v. propranolol (7.5 mg/Kg) or placebo in rats with portal hypertension due to PPVL and sham operated controls. Results: PPVL rats had an increased VC when compared to Sham (4.9±1.4 vs. 3.7±0.9 ml kg^-1 mmHg^-1; P

Original language	English
Pages (from-to)	1040-1045
Number of pages	6
Journal	Journal of Hepatology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/j.jhep.2005.10.024
Publication status	Published - Jun 2006

Keywords

Conscious rats
Portal hypertension
Portal vein ligation
Propranolol
Venous compliance

ASJC Scopus subject areas

Gastroenterology

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Andreu, V., Garcia-Pagan, J. C., Lionetti, R., Piera, C., Abraldes, J. G., & Bosch, J. (2006). Effects of propranolol on venous compliance in conscious rats with pre-hepatic portal hypertension. Journal of Hepatology, 44(6), 1040-1045. https://doi.org/10.1016/j.jhep.2005.10.024

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abstract = "Background/Aims: The venous system is the primary capacitance region in the body. However, the influence of active changes in the venous system on the hemodynamic alterations of portal hypertension is poorly understood. To investigate venous compliance (VC) in conscious partial portal vein ligated rats (PPVL) and the effect of propranolol on VC. Methods: Venous compliance was derived from the relationship between changes in mean circulatory filling pressure (MCFP) and changes in blood volume (BV). Measurements were performed before and after i.v. propranolol (7.5 mg/Kg) or placebo in rats with portal hypertension due to PPVL and sham operated controls. Results: PPVL rats had an increased VC when compared to Sham (4.9±1.4 vs. 3.7±0.9 ml kg-1 mmHg-1; P",

keywords = "Conscious rats, Portal hypertension, Portal vein ligation, Propranolol, Venous compliance",

author = "Victoria Andreu and Garcia-Pagan, {Juan Carlos} and Raffaela Lionetti and Carlos Piera and Abraldes, {Juan G.} and Jaume Bosch",

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AU - Andreu, Victoria

AU - Garcia-Pagan, Juan Carlos

AU - Lionetti, Raffaela

AU - Piera, Carlos

AU - Abraldes, Juan G.

AU - Bosch, Jaume

PY - 2006/6

Y1 - 2006/6

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AB - Background/Aims: The venous system is the primary capacitance region in the body. However, the influence of active changes in the venous system on the hemodynamic alterations of portal hypertension is poorly understood. To investigate venous compliance (VC) in conscious partial portal vein ligated rats (PPVL) and the effect of propranolol on VC. Methods: Venous compliance was derived from the relationship between changes in mean circulatory filling pressure (MCFP) and changes in blood volume (BV). Measurements were performed before and after i.v. propranolol (7.5 mg/Kg) or placebo in rats with portal hypertension due to PPVL and sham operated controls. Results: PPVL rats had an increased VC when compared to Sham (4.9±1.4 vs. 3.7±0.9 ml kg-1 mmHg-1; P

KW - Conscious rats

KW - Portal hypertension

KW - Portal vein ligation

KW - Propranolol

KW - Venous compliance

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