Effects of prostaglandin E1α cyclodestrin treatment on endothelial dysfunction in patients with systemic sclerosis

Cristina Giannattasio, MariaRosa Pozzi, Marco Gradinali, Elisabetta Montemerlo, Francesca Citterio, Silvia Maestroni, Elena Fantini, Monica Failla, Maria Robuschi, Salvatore Bianco, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: Systemic sclerosis (SSc) is characterized by an altered nitric oxide (NO): endothelin I ratio and by endothelial dysfunction. AIMS: To verify the effects of prostaglandin E1 (PGE1) α-cyclodestrin treatment on endothelial function, quantified as flow-mediated dilation (FMD) of the radial artery. METHODS: In 16 women with SSc (age 57 ± 2.7 years, means ± SE) in whom a diagnosis of SSc had been made several years earlier (7.1 ± 1.2 years), FMD was evaluated by an echotracking technique on the radial artery, using trinitroglycerin vasodilation as a non-endothelial measure of the vessel's ability to increase its diameter maximally. FMD was evaluated after 4 months washout period and after 4 months cyclic infusion of PGE1 α-cyclodestrin. Expired NO was measured at the same time. RESULTS: PGE1 α-cyclodestrin cyclic infusions did not modify systolic and diastolic blood pressure, heart rate or trinitroglycerin radial artery vasodilation. On the other hand, it induced a marked and significant increase in FMD of the radial artery, which was also accompanied by an increase in blood flow and expired NO. CONCLUSIONS: Endothelial dysfunction and reduced FMD associated with SSc are improved by cyclic treatment with PGE1 α-cyclodestrin. This effect occurs together with a concomitant increase in expired NO, suggesting its direct positive influence on endothelial function. It may also partly explain the clinical beneficial effect of the drug in SSc.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalJournal of Hypertension
Volume25
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Alfa 1 cycodestrin
  • Arterial vessel
  • Endothelium
  • Raynaud disease
  • Systemic sclerosis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

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