Effetti della prostaglandina PGE1 alfa-ciclodestrina sul microcircolo cutaneo. Valutazione flussimetrica e termografica

Translated title of the contribution: Effects of prostaglandin PGE1 on cutaneous microcirculation. Flowmeter and thermographic assessment

F. Distante, E. Berardesca, L. Miori, G. Rabbiosi

Research output: Contribution to journalArticle


Background. In this study, the efficacy of PGE1 therapy was evaluated to improve cutaneous microcirculation in patient suffering from progressive systemic sclerosis (PSS) and Raynaud's phenomenon and from chronic ischemic wounds of legs. Methods. Sixteen subjects were included in the trial; 13 of them were suffering from PSS and Raynaud's phenomenon; 3 of them from ischemic ulcers of legs. The subjects were treated with 60 μg/die of PGE1 alpha-ciclodestrin in saline intravenous infusion. Cutaneous microcirculation was assessed by means of contact thermography with image analysis and laser Doppler flowmeter with reactive hyperemic test. From the analysis of this test, baseline skin blood flow, the area under the curve of maximal vasodilatation (AUC) and the maximal hyperemic response (max peak) was calculated. Results. The results show a statistically significant increase of limb skin temperature, of AUC and maximal hyperemic response values. Baseline mean flux values, though increased, were not statistically significantly changed. Conclusions. The conclusion is drawn that PGE1 can be an effective support in cutaneous vascular disease therapy. The mechanism of action of this compound could be related to an improvement of microcirculation modulation in response to neurovegetative triggers.

Original languageItalian
Pages (from-to)67-72
Number of pages6
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number1
Publication statusPublished - 1999


ASJC Scopus subject areas

  • Dermatology

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