Effects of raloxifene on sex steroid hormones and C-telopeptide in postmenopausal women with primary breast cancer

Research output: Contribution to journalArticle

Abstract

Within a multicentric, double-blind, placebo-controlled phase II trial, postmenopausal women with primary breast cancer were randomized to either 60 or 600 mg daily of raloxifene or placebo administered for 2 weeks prior to surgery. Circulating levels of sex-hormone binding globulin (SHBG), dehydroepiandrosterone-sulfate (DHEA-S), estrone (E1), estrone-sulfate (E1-S), estradiol (E2), and C-terminal telopeptide (CTX), were determined at baseline and the day before surgery in 37 women enrolled at the European Institute of Oncology in Milan. Raloxifene had a statistically significant different effect compared with placebo on SHBG (p

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalBreast Cancer Research and Treatment
Volume98
Issue number2
DOIs
Publication statusPublished - Jul 2006

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Keywords

  • Biomarkers
  • Bone resorption
  • Breast cancer
  • Chemoprevention
  • Estrogen
  • Raloxifene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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