Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study

Y. Lévy; I. Sereti; G. Tambussi; J. P. Routy; J. D. Lelièvre; J. F. Delfraissy; J. M. Molina; M. Fischl; C. Goujard; B. Rodriguez; C. Rouzioux; V. Avettand-Fenoël; T. Croughs; S. Beq; M. Morre; J. F. Poulin; R. P. Sekaly; R. Thiebaut; M. M. Lederman

doi:10.1093/cid/cis383

Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study

Y. Lévy, I. Sereti, G. Tambussi, J. P. Routy, J. D. Lelièvre, J. F. Delfraissy, J. M. Molina, M. Fischl, C. Goujard, B. Rodriguez, C. Rouzioux, V. Avettand-Fenoël, T. Croughs, S. Beq, M. Morre, J. F. Poulin, R. P. Sekaly, R. Thiebaut, M. M. Lederman

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but optimal dosing and mechanisms of cellular increases need to be defined. Methods. We performed a randomized placebo-controlled dose escalation (10, 20 and 30 g/kg) trial of 3 weekly doses of recombinant human IL-7 (rhIL-7) in ARV-treated HIV-infected persons with CD4 T-cell counts between 101 and 400 cells/L and plasma HIV levels

Original language	English
Pages (from-to)	291-300
Number of pages	10
Journal	Clinical Infectious Diseases
Volume	55
Issue number	2
DOIs	https://doi.org/10.1093/cid/cis383
Publication status	Published - Jul 15 2012

ASJC Scopus subject areas

Infectious Diseases
Microbiology (medical)

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Lévy, Y., Sereti, I., Tambussi, G., Routy, J. P., Lelièvre, J. D., Delfraissy, J. F., Molina, J. M., Fischl, M., Goujard, C., Rodriguez, B., Rouzioux, C., Avettand-Fenoël, V., Croughs, T., Beq, S., Morre, M., Poulin, J. F., Sekaly, R. P., Thiebaut, R., & Lederman, M. M. (2012). Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clinical Infectious Diseases, 55(2), 291-300. https://doi.org/10.1093/cid/cis383

Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy : Results of a phase I/IIa randomized, placebo-controlled, multicenter study. / Lévy, Y.; Sereti, I.; Tambussi, G.; Routy, J. P.; Lelièvre, J. D.; Delfraissy, J. F.; Molina, J. M.; Fischl, M.; Goujard, C.; Rodriguez, B.; Rouzioux, C.; Avettand-Fenoël, V.; Croughs, T.; Beq, S.; Morre, M.; Poulin, J. F.; Sekaly, R. P.; Thiebaut, R.; Lederman, M. M.

In: Clinical Infectious Diseases, Vol. 55, No. 2, 15.07.2012, p. 291-300.

Research output: Contribution to journal › Article › peer-review

Lévy, Y, Sereti, I, Tambussi, G, Routy, JP, Lelièvre, JD, Delfraissy, JF, Molina, JM, Fischl, M, Goujard, C, Rodriguez, B, Rouzioux, C, Avettand-Fenoël, V, Croughs, T, Beq, S, Morre, M, Poulin, JF, Sekaly, RP, Thiebaut, R & Lederman, MM 2012, 'Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study', Clinical Infectious Diseases, vol. 55, no. 2, pp. 291-300. https://doi.org/10.1093/cid/cis383

Lévy Y, Sereti I, Tambussi G, Routy JP, Lelièvre JD, Delfraissy JF et al. Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clinical Infectious Diseases. 2012 Jul 15;55(2):291-300. https://doi.org/10.1093/cid/cis383

Lévy, Y. ; Sereti, I. ; Tambussi, G. ; Routy, J. P. ; Lelièvre, J. D. ; Delfraissy, J. F. ; Molina, J. M. ; Fischl, M. ; Goujard, C. ; Rodriguez, B. ; Rouzioux, C. ; Avettand-Fenoël, V. ; Croughs, T. ; Beq, S. ; Morre, M. ; Poulin, J. F. ; Sekaly, R. P. ; Thiebaut, R. ; Lederman, M. M. / Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy : Results of a phase I/IIa randomized, placebo-controlled, multicenter study. In: Clinical Infectious Diseases. 2012 ; Vol. 55, No. 2. pp. 291-300.

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abstract = "Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but optimal dosing and mechanisms of cellular increases need to be defined. Methods. We performed a randomized placebo-controlled dose escalation (10, 20 and 30 g/kg) trial of 3 weekly doses of recombinant human IL-7 (rhIL-7) in ARV-treated HIV-infected persons with CD4 T-cell counts between 101 and 400 cells/L and plasma HIV levels ",

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AU - Sereti, I.

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AU - Lelièvre, J. D.

AU - Delfraissy, J. F.

AU - Molina, J. M.

AU - Fischl, M.

AU - Goujard, C.

AU - Rodriguez, B.

AU - Rouzioux, C.

AU - Avettand-Fenoël, V.

AU - Croughs, T.

AU - Beq, S.

AU - Morre, M.

AU - Poulin, J. F.

AU - Sekaly, R. P.

AU - Thiebaut, R.

AU - Lederman, M. M.

PY - 2012/7/15

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Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study

Abstract

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