Effects of recombinant murine (rm) interleukin-12 and rm interferon-γ in mice infected with Bordetella pertussis

Donato Torre, Filippo Speranza, Agostino Pugliese, Lorenza Perversi, Piero Marone, Giulio Ferrario

Research output: Contribution to journalArticlepeer-review

Abstract

The recombinant cytokines interferon (IFN)-γ and interleukin (IL)-12 stimulate several macrophage-mediated functions that are important in host defense. An experimental pertussis model showed that intraperitoneal (ip) administration of 10,000 U of recombinant murine (rm) IFN-γ to mice at the time of Bordetella pertussis infection caused a marked and significant reduction in the number of colony-forming units of bacteria in the lungs. Administration ip of 1 μg of rmIL-12 or 1 μg of rmIL-12 at the time of and for 5 consecutive days after B. pertussis challenge also induced a significant reduction in the number. However, ip administration of 1 μg of rmIL-12 with 10,000 U of IFN-γ at the time of B. pertussis challenge did not provide protection. These findings indicate that exogenous administration of rmIL-12 and rmIFN-γ enhances resistance of mice to B. pertussis infection.

Original languageEnglish
Pages (from-to)786-789
Number of pages4
JournalJournal of Infectious Diseases
Volume174
Issue number4
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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