The recombinant cytokines interferon (IFN)-γ and interleukin (IL)-12 stimulate several macrophage-mediated functions that are important in host defense. An experimental pertussis model showed that intraperitoneal (ip) administration of 10,000 U of recombinant murine (rm) IFN-γ to mice at the time of Bordetella pertussis infection caused a marked and significant reduction in the number of colony-forming units of bacteria in the lungs. Administration ip of 1 μg of rmIL-12 or 1 μg of rmIL-12 at the time of and for 5 consecutive days after B. pertussis challenge also induced a significant reduction in the number. However, ip administration of 1 μg of rmIL-12 with 10,000 U of IFN-γ at the time of B. pertussis challenge did not provide protection. These findings indicate that exogenous administration of rmIL-12 and rmIFN-γ enhances resistance of mice to B. pertussis infection.
|Number of pages||4|
|Journal||Journal of Infectious Diseases|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health