Abstract
In anesthetized cats head-up tilting for 30 min and infusion of furosemide at 0.75 mg/kg in 30 min significantly raised renin release from the innervated kidney (increments of 90.7±21.4 ng/min on tilting and 105.4±26.4 ng/min after furosemide); a small and inconstant increase from the contralateral denervated kidney (increments of 16.8±16.0 and 16.3±17.7 ng/min, resp.) was abolished by acute bilateral adrenalectomy. Larger doses of furosemide (6.0 mg/kg) could release renin from the denervated kidney also, but the response was still more marked on the innervated side especially in the early period of infusion (increments of 132.7±23.8 and 33.7±23.8 ng/min on innervated and denervated sides at 10 min). The response of the denervated kidney to 6.0 mg furosemide/kg was not affected by adrenalectomy. Stimulation of juxtaglomerular cells by tilting is entirely due to sympathoadrenergic activation; stimulation by furosemide is also entirely neural when the diuretic drug is given in moderate doses, but is partly independent of innervation when larger doses are administered.
| Original language | English |
|---|---|
| Title of host publication | American Journal of Physiology |
| Volume | 232 |
| Edition | 5 |
| Publication status | Published - 1977 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Effects of renal denervation on renin release in response to tilting and furosemide. / Stella, A.; Zanchetti, A.
American Journal of Physiology. Vol. 232 5. ed. 1977.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Effects of renal denervation on renin release in response to tilting and furosemide
AU - Stella, A.
AU - Zanchetti, A.
PY - 1977
Y1 - 1977
N2 - In anesthetized cats head-up tilting for 30 min and infusion of furosemide at 0.75 mg/kg in 30 min significantly raised renin release from the innervated kidney (increments of 90.7±21.4 ng/min on tilting and 105.4±26.4 ng/min after furosemide); a small and inconstant increase from the contralateral denervated kidney (increments of 16.8±16.0 and 16.3±17.7 ng/min, resp.) was abolished by acute bilateral adrenalectomy. Larger doses of furosemide (6.0 mg/kg) could release renin from the denervated kidney also, but the response was still more marked on the innervated side especially in the early period of infusion (increments of 132.7±23.8 and 33.7±23.8 ng/min on innervated and denervated sides at 10 min). The response of the denervated kidney to 6.0 mg furosemide/kg was not affected by adrenalectomy. Stimulation of juxtaglomerular cells by tilting is entirely due to sympathoadrenergic activation; stimulation by furosemide is also entirely neural when the diuretic drug is given in moderate doses, but is partly independent of innervation when larger doses are administered.
AB - In anesthetized cats head-up tilting for 30 min and infusion of furosemide at 0.75 mg/kg in 30 min significantly raised renin release from the innervated kidney (increments of 90.7±21.4 ng/min on tilting and 105.4±26.4 ng/min after furosemide); a small and inconstant increase from the contralateral denervated kidney (increments of 16.8±16.0 and 16.3±17.7 ng/min, resp.) was abolished by acute bilateral adrenalectomy. Larger doses of furosemide (6.0 mg/kg) could release renin from the denervated kidney also, but the response was still more marked on the innervated side especially in the early period of infusion (increments of 132.7±23.8 and 33.7±23.8 ng/min on innervated and denervated sides at 10 min). The response of the denervated kidney to 6.0 mg furosemide/kg was not affected by adrenalectomy. Stimulation of juxtaglomerular cells by tilting is entirely due to sympathoadrenergic activation; stimulation by furosemide is also entirely neural when the diuretic drug is given in moderate doses, but is partly independent of innervation when larger doses are administered.
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M3 - Chapter
VL - 232
BT - American Journal of Physiology
ER -