Effects of Renal Sympathetic Denervation on Arterial Stiffness and Blood Pressure Control in Resistant Hypertensive Patients: A Single Centre Prospective Study

Matteo Baroni, Stefano Nava, Luca Giupponi, Paolo Meani, Francesco Panzeri, Marisa Varrenti, Alessandro Maloberti, Francesco Soriano, Antonio Maria Agrati, Giovanni Ferraro, Fabrizio Colombo, Antonio Rampoldi, Giuseppe Mancia, Paola Colombo, Silvio Klugmann, Cristina Giannattasio

Research output: Contribution to journalArticlepeer-review

Abstract

Renal denervation (RD) is an intriguing treatment strategy for resistant hypertension. However, limited data are available about its long time efficacy as well as its effects on intermediate phenotypes like arterial stiffness and carotid IMT. 12 patients (9 males, mean 69 years) with resistant hypertension underwent bilateral RDN (Medtronic System) since April 2012 in Niguarda Ca’ Granda Hospital (Milan). Patients were studied before intervention, and at 1, 3, 6 and 12 months after RD. Carotid intima media thickness (Esaote Mylab) and carotid-femoral pulse wave velocity (Complior, Alam medical) were assessed at each step. Compared to baseline, patients showed a marked reduction of office systolic blood pressure at each follow-up step (p 

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume22
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Arterial stiffness
  • Cardiovascular risk
  • Essential hypertension
  • Renal sympathetic denervation
  • Resistant hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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