Abstract
Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 μg/kg, s.c.) induced a sevenfold increase in anterior pituitary γ-aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight-day estradiol benzoate injection also enhanced the V(max) of median eminence glutamate decarboxylase activity without affecting the K(m) of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero-infundibular GABAergic system in male rats.
| Original language | English |
|---|---|
| Pages (from-to) | 1217-1220 |
| Number of pages | 4 |
| Journal | Journal of Neurochemistry |
| Volume | 44 |
| Issue number | 4 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats. / Nicoletti, F.; Grandison, L.; Meek, J. L.
In: Journal of Neurochemistry, Vol. 44, No. 4, 1985, p. 1217-1220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats
AU - Nicoletti, F.
AU - Grandison, L.
AU - Meek, J. L.
PY - 1985
Y1 - 1985
N2 - Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 μg/kg, s.c.) induced a sevenfold increase in anterior pituitary γ-aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight-day estradiol benzoate injection also enhanced the V(max) of median eminence glutamate decarboxylase activity without affecting the K(m) of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero-infundibular GABAergic system in male rats.
AB - Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 μg/kg, s.c.) induced a sevenfold increase in anterior pituitary γ-aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight-day estradiol benzoate injection also enhanced the V(max) of median eminence glutamate decarboxylase activity without affecting the K(m) of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero-infundibular GABAergic system in male rats.
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M3 - Article
VL - 44
SP - 1217
EP - 1220
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 4
ER -