Effects of repeated methamphetamine administration on methamphetamine self-administration in rhesus monkeys

W. L. Woolverton, L. Cervo, C. E. Johanson

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Abstract

The effects of prolonged exposure to high doses of stimulants self-administration in rhesus monkeys have not been established. In the present experiment, rates of methamphetamine self-administration as well as the effects of methamphetamine on food-maintained responding were determined before and after a regimen of repeated methamphetamine injections. Increases in self-administration of some doses of methamphetamine as well as tolerance to the rate-decreasing effects of the drug on food-maintained responding were observed following the repeated injection regimen. The results suggest that while tolerance may develop to the rate-decreasing effects of the drug, there may be an increased sensitivity to its reinforcing properties. In addition, since this injection regimen has been shown in previous studies to deplete central monoamines, especially dopamine, the results suggest a role for these monoamines in these behavioral effects of methamphetamine.

Original languageEnglish
Pages (from-to)737-741
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume21
Issue number5
Publication statusPublished - 1984

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Self Administration
Methamphetamine
Macaca mulatta
Injections
Food
Pharmaceutical Preparations
Dopamine
Experiments

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of repeated methamphetamine administration on methamphetamine self-administration in rhesus monkeys. / Woolverton, W. L.; Cervo, L.; Johanson, C. E.

In: Pharmacology, Biochemistry and Behavior, Vol. 21, No. 5, 1984, p. 737-741.

Research output: Contribution to journalArticle

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