Abstract
The effects of prolonged exposure to high doses of stimulants self-administration in rhesus monkeys have not been established. In the present experiment, rates of methamphetamine self-administration as well as the effects of methamphetamine on food-maintained responding were determined before and after a regimen of repeated methamphetamine injections. Increases in self-administration of some doses of methamphetamine as well as tolerance to the rate-decreasing effects of the drug on food-maintained responding were observed following the repeated injection regimen. The results suggest that while tolerance may develop to the rate-decreasing effects of the drug, there may be an increased sensitivity to its reinforcing properties. In addition, since this injection regimen has been shown in previous studies to deplete central monoamines, especially dopamine, the results suggest a role for these monoamines in these behavioral effects of methamphetamine.
| Original language | English |
|---|---|
| Pages (from-to) | 737-741 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 21 |
| Issue number | 5 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
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Effects of repeated methamphetamine administration on methamphetamine self-administration in rhesus monkeys. / Woolverton, W. L.; Cervo, L.; Johanson, C. E.
In: Pharmacology, Biochemistry and Behavior, Vol. 21, No. 5, 1984, p. 737-741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of repeated methamphetamine administration on methamphetamine self-administration in rhesus monkeys
AU - Woolverton, W. L.
AU - Cervo, L.
AU - Johanson, C. E.
PY - 1984
Y1 - 1984
N2 - The effects of prolonged exposure to high doses of stimulants self-administration in rhesus monkeys have not been established. In the present experiment, rates of methamphetamine self-administration as well as the effects of methamphetamine on food-maintained responding were determined before and after a regimen of repeated methamphetamine injections. Increases in self-administration of some doses of methamphetamine as well as tolerance to the rate-decreasing effects of the drug on food-maintained responding were observed following the repeated injection regimen. The results suggest that while tolerance may develop to the rate-decreasing effects of the drug, there may be an increased sensitivity to its reinforcing properties. In addition, since this injection regimen has been shown in previous studies to deplete central monoamines, especially dopamine, the results suggest a role for these monoamines in these behavioral effects of methamphetamine.
AB - The effects of prolonged exposure to high doses of stimulants self-administration in rhesus monkeys have not been established. In the present experiment, rates of methamphetamine self-administration as well as the effects of methamphetamine on food-maintained responding were determined before and after a regimen of repeated methamphetamine injections. Increases in self-administration of some doses of methamphetamine as well as tolerance to the rate-decreasing effects of the drug on food-maintained responding were observed following the repeated injection regimen. The results suggest that while tolerance may develop to the rate-decreasing effects of the drug, there may be an increased sensitivity to its reinforcing properties. In addition, since this injection regimen has been shown in previous studies to deplete central monoamines, especially dopamine, the results suggest a role for these monoamines in these behavioral effects of methamphetamine.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021750842&partnerID=8YFLogxK
M3 - Article
VL - 21
SP - 737
EP - 741
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 5
ER -