Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain

Marco Gobbi, Alessandra Bergami, Cristina Caltavuturo, Fabio Dalla Valle, Tiziana Mennini, Silvio Caccia

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of oral dexnorfenfluramine (DNF; 1-4 mg/kg, twice daily for 4 days), the active metabolite of dexfenfluramine, were examined on rat regional brain indole contents and [3H]citalopram binding. Two hours after the last dose, serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were dose-dependently lowered at doses above 1.5 mg/kg, with slight regional differences. Cortical 5-HT uptake sites were reduced only at the highest dose. Above 2 mg/kg DNF also caused a more lasting reduction (4 weeks) of regional indoles and cortical 5-HT uptake sites. At this longer time while the decrease in hippocampal 5-HT levels and cortical 5-HT uptake sites remained essentially constant, cortical and striatal 5-HT levels were lowered less than at 2 h, suggesting a return toward control values.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume219
Issue number1
DOIs
Publication statusPublished - Nov 15 1996

Keywords

  • Dexnorfenfluramine
  • Rat brain
  • Serotonin
  • Serotonin uptake sites

ASJC Scopus subject areas

  • Neuroscience(all)

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