Effects of repetitive cortical stimulation on the silent period evoked by magnetic stimulation

A. Berardelli, M. Inghilleri, F. Gilio, S. Romeo, F. Pedace, A. Currà, M. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of repetitive transcranial stimulation (rTMS) on brain activity remain unknown. In healthy subjects, we studied the effects of rTMS on the duration of the cortical silent period (SP). Repetitive stimuli were delivered with a Cadwell High Speed Magnetic Stimulator and a figure-of-eight coil placed over the hand motor area. rTMS was delivered in trains of 11 or 20 stimuli at frequencies of 3 and 5 Hz and at stimulation intensities of 110 and 120% of motor threshold. The SP was recorded from the forearm muscles during a voluntary contraction (20% of maximum effort). rTMS delivered at a frequency of 3 and 5 Hz and intensities of 110 and 120% motor threshold prolonged the duration of the SP, without modifying either the size or the latency of the muscle-evoked potentials (MEP). A conditioning train of 11 stimuli at 3 Hz had no effect on the duration of the SP evoked by a single magnetic shock delivered 600 ms after the train. These findings show that rTMS increases the duration of the cortical SP, but does so only during the train of stimuli. rTMS probably changes the duration of the SP by facilitating cortical inhibitory interneurons.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalExperimental Brain Research
Volume125
Issue number1
DOIs
Publication statusPublished - 1999

Keywords

  • Cortical motor areas
  • Magnetic stimulation
  • Repetitive stimulation
  • Silent period

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Effects of repetitive cortical stimulation on the silent period evoked by magnetic stimulation'. Together they form a unique fingerprint.

Cite this