Effects of repetitive transcranial magnetic stimulation in a patient with fixation-off sensitivity

O. Mecarelli, B. Gregori, F. Gilio, A. Conte, V. Frasca, N. Accornero, M. Inghilleri

Research output: Contribution to journalArticle

Abstract

Aim of the present study was to evaluate the acute and long-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on focal epileptiform interictal EEG activity in a patient with fixation-off sensitivity and partial epilepsy. Real and sham rTMS were delivered over the vertex. Two trains of 500 stimuli per day were delivered at 0.33 Hz frequency and threshold intensity for five consecutive days. The number of posterior EEG spikes and spike-and-wave complexes/min before and after the application of rTMS were compared in a blinded manner. In our patient, real-rTMS induced a long-lasting decrease in the number of posterior EEG spikes and spike-and-wave complexes/min. Despite the limitations of a single case report, our study confirms that low-frequency rTMS significantly reduces interictal focal epileptic activity over time.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalExperimental Brain Research
Volume173
Issue number1
DOIs
Publication statusPublished - Aug 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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