Abstract
Background: In previous studies we found that high-frequency somatosensory oscillations (HFOs) reflecting thalamo-cortical activation were decreased in migraineurs between attacks and that high-frequency repetitive transcranial magnetic stimulation (rTMS) was able to normalize the habituation deficit of visual evoked potentials (VEPs). Here we study the effects of activating (10-Hz) or inhibiting (1-Hz) rTMS on conventional low-frequency (LF) and high-frequency somatosensory evoked potentials (SSEPs).Subjects and methods: rTMS was applied on the motor cortex of 13 healthy volunteers (HVs) and 13 migraine without aura (MO) patients. We measured N20-P25 LF-SSEP amplitude and habituation, and maximal peak-to-peak amplitude of early and late HFOs before and after rTMS.Results: In HVs, 1-Hz-rTMS significantly reduced the amplitude of the first LF-SSEP block and its habituation. In MO patients, 10-Hz-rTMS increased the amplitude of the first block and induced habituation. Ten Hz rTMS produced an increase of late HFO in both groups, but more interestingly, in MO patients also significantly increased the early HFOs, which are reduced at baseline compared to those of HVs.Conclusions: These data confirm for SSEP that excitatory rTMS can normalize habituation in migraine patients and show that this is accompanied by early an HFO increase, which is thought to reflect thalamo-cortical activity. Taken together with similar effects we observed for VEPs, this finding supports the hypothesis that dysfunctioning thalamo-cortical loops may be responsible for the interictal habituation deficit in migraine.
| Original language | English |
|---|---|
| Pages (from-to) | 700-709 |
| Number of pages | 10 |
| Journal | Cephalalgia |
| Volume | 32 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jul 2012 |
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Keywords
- habituation
- High-frequency oscillations
- migraine
- repetitive transcranial magnetic stimulation
- somatosensory evoked potentials
- thalamo-cortical activity
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Effects of repetitive transcranial magnetic stimulation on somatosensory evoked potentials and high frequency oscillations in migraine. / Coppola, Gianluca; De Pasqua, Victor; Pierelli, Francesco; Schoenen, Jean.
In: Cephalalgia, Vol. 32, No. 9, 07.2012, p. 700-709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of repetitive transcranial magnetic stimulation on somatosensory evoked potentials and high frequency oscillations in migraine
AU - Coppola, Gianluca
AU - De Pasqua, Victor
AU - Pierelli, Francesco
AU - Schoenen, Jean
PY - 2012/7
Y1 - 2012/7
N2 - Background: In previous studies we found that high-frequency somatosensory oscillations (HFOs) reflecting thalamo-cortical activation were decreased in migraineurs between attacks and that high-frequency repetitive transcranial magnetic stimulation (rTMS) was able to normalize the habituation deficit of visual evoked potentials (VEPs). Here we study the effects of activating (10-Hz) or inhibiting (1-Hz) rTMS on conventional low-frequency (LF) and high-frequency somatosensory evoked potentials (SSEPs).Subjects and methods: rTMS was applied on the motor cortex of 13 healthy volunteers (HVs) and 13 migraine without aura (MO) patients. We measured N20-P25 LF-SSEP amplitude and habituation, and maximal peak-to-peak amplitude of early and late HFOs before and after rTMS.Results: In HVs, 1-Hz-rTMS significantly reduced the amplitude of the first LF-SSEP block and its habituation. In MO patients, 10-Hz-rTMS increased the amplitude of the first block and induced habituation. Ten Hz rTMS produced an increase of late HFO in both groups, but more interestingly, in MO patients also significantly increased the early HFOs, which are reduced at baseline compared to those of HVs.Conclusions: These data confirm for SSEP that excitatory rTMS can normalize habituation in migraine patients and show that this is accompanied by early an HFO increase, which is thought to reflect thalamo-cortical activity. Taken together with similar effects we observed for VEPs, this finding supports the hypothesis that dysfunctioning thalamo-cortical loops may be responsible for the interictal habituation deficit in migraine.
AB - Background: In previous studies we found that high-frequency somatosensory oscillations (HFOs) reflecting thalamo-cortical activation were decreased in migraineurs between attacks and that high-frequency repetitive transcranial magnetic stimulation (rTMS) was able to normalize the habituation deficit of visual evoked potentials (VEPs). Here we study the effects of activating (10-Hz) or inhibiting (1-Hz) rTMS on conventional low-frequency (LF) and high-frequency somatosensory evoked potentials (SSEPs).Subjects and methods: rTMS was applied on the motor cortex of 13 healthy volunteers (HVs) and 13 migraine without aura (MO) patients. We measured N20-P25 LF-SSEP amplitude and habituation, and maximal peak-to-peak amplitude of early and late HFOs before and after rTMS.Results: In HVs, 1-Hz-rTMS significantly reduced the amplitude of the first LF-SSEP block and its habituation. In MO patients, 10-Hz-rTMS increased the amplitude of the first block and induced habituation. Ten Hz rTMS produced an increase of late HFO in both groups, but more interestingly, in MO patients also significantly increased the early HFOs, which are reduced at baseline compared to those of HVs.Conclusions: These data confirm for SSEP that excitatory rTMS can normalize habituation in migraine patients and show that this is accompanied by early an HFO increase, which is thought to reflect thalamo-cortical activity. Taken together with similar effects we observed for VEPs, this finding supports the hypothesis that dysfunctioning thalamo-cortical loops may be responsible for the interictal habituation deficit in migraine.
KW - habituation
KW - High-frequency oscillations
KW - migraine
KW - repetitive transcranial magnetic stimulation
KW - somatosensory evoked potentials
KW - thalamo-cortical activity
UR - http://www.scopus.com/inward/record.url?scp=84863713998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863713998&partnerID=8YFLogxK
U2 - 10.1177/0333102412446313
DO - 10.1177/0333102412446313
M3 - Article
C2 - 22652384
AN - SCOPUS:84863713998
VL - 32
SP - 700
EP - 709
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 9
ER -