The survival of motor neuron (SMN) gene is implicated in spinal muscular atrophy (SMA), a neurodegenerative disease of ventral horn motor neurons. The authors, utilizing an immunofluorescent tecnique have evaluated: (a) SMN expression in a human neuroblastoma cell line and in two phenotypically distinct clones derived from it; (b) SMN variability induced by retinoids treatment. Results are discussed in relation to a possible SMN antiapoptotic role and to its use as a neurodifferentiative marker.
|Number of pages||8|
|Journal||Acta Medica Romana|
|Publication status||Published - 2000|
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