Effects of retinoids on the expression of the survival of motor neurons gene in human neuroblastoma cells

C. Andreassi, A. L. Patrizi, M. Annicchiarico-Petruzzelli, G. Melino, C. Brahe, M. L. Eboli

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Abstract

The survival of motor neuron (SMN) gene is implicated in spinal muscular atrophy (SMA), a neurodegenerative disease of ventral horn motor neurons. The authors, utilizing an immunofluorescent tecnique have evaluated: (a) SMN expression in a human neuroblastoma cell line and in two phenotypically distinct clones derived from it; (b) SMN variability induced by retinoids treatment. Results are discussed in relation to a possible SMN antiapoptotic role and to its use as a neurodifferentiative marker.

Original languageEnglish
Pages (from-to)379-386
Number of pages8
JournalActa Medica Romana
Volume38
Issue number4
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Medicine(all)

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