Effects of reversible renal denervation on haemodynamic and excretory functions of the ipsilateral and contralateral kidney in the cat

Andrea Stella, Raffaello Golin, Alberto Zanchetti

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In anaesthetized cats reversible denervation of one kidney was performed by cooling of the left renal nerves to 3°C for 16 min. The response of the left (ipsilateral) kidney was compared with the response of the right (contralateral) kidney twice in the same animal: (1) when the right kidney was still innervated, and (2) after it had been surgically denervated. Left renal nerve cooling did not cause any changes in arterial pressure. In the left kidney, blood flow, vascular conductance, sodium and water excretions increased, and renin release decreased. Simultaneously in the contralateral kidney, no haemodynamic changes were observed, glomerular filtration was only transiently decreased, whereas sodium and water excretion significantly decreased and renin release increased. When left renal nerve cooling was repeated after surgical denervation of the right kidney, similar changes were observed in the left (ipsilateral) kidney, whereas all contralateral effects were abolished. These experiments suggest that tonically active afferent fibres from one kidney exert a reflex inhibitory action on sympathetic activity directed to the contralateral kidney controlling tubular sodium reabsorption and renin release.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalJournal of Hypertension
Volume4
Issue number2
Publication statusPublished - 1986

Fingerprint

Denervation
Cats
Hemodynamics
Kidney
Renin
Sodium
Water
Blood Vessels
Reflex
Arterial Pressure

Keywords

  • Cooling
  • Dieresis
  • Natriuresis
  • Renal nerves
  • Rennin
  • Renorenal reflexes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Effects of reversible renal denervation on haemodynamic and excretory functions of the ipsilateral and contralateral kidney in the cat. / Stella, Andrea; Golin, Raffaello; Zanchetti, Alberto.

In: Journal of Hypertension, Vol. 4, No. 2, 1986, p. 181-188.

Research output: Contribution to journalArticle

@article{831e258cd0364523b4e329cf27b6729e,
title = "Effects of reversible renal denervation on haemodynamic and excretory functions of the ipsilateral and contralateral kidney in the cat",
abstract = "In anaesthetized cats reversible denervation of one kidney was performed by cooling of the left renal nerves to 3°C for 16 min. The response of the left (ipsilateral) kidney was compared with the response of the right (contralateral) kidney twice in the same animal: (1) when the right kidney was still innervated, and (2) after it had been surgically denervated. Left renal nerve cooling did not cause any changes in arterial pressure. In the left kidney, blood flow, vascular conductance, sodium and water excretions increased, and renin release decreased. Simultaneously in the contralateral kidney, no haemodynamic changes were observed, glomerular filtration was only transiently decreased, whereas sodium and water excretion significantly decreased and renin release increased. When left renal nerve cooling was repeated after surgical denervation of the right kidney, similar changes were observed in the left (ipsilateral) kidney, whereas all contralateral effects were abolished. These experiments suggest that tonically active afferent fibres from one kidney exert a reflex inhibitory action on sympathetic activity directed to the contralateral kidney controlling tubular sodium reabsorption and renin release.",
keywords = "Cooling, Dieresis, Natriuresis, Renal nerves, Rennin, Renorenal reflexes",
author = "Andrea Stella and Raffaello Golin and Alberto Zanchetti",
year = "1986",
language = "English",
volume = "4",
pages = "181--188",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Effects of reversible renal denervation on haemodynamic and excretory functions of the ipsilateral and contralateral kidney in the cat

AU - Stella, Andrea

AU - Golin, Raffaello

AU - Zanchetti, Alberto

PY - 1986

Y1 - 1986

N2 - In anaesthetized cats reversible denervation of one kidney was performed by cooling of the left renal nerves to 3°C for 16 min. The response of the left (ipsilateral) kidney was compared with the response of the right (contralateral) kidney twice in the same animal: (1) when the right kidney was still innervated, and (2) after it had been surgically denervated. Left renal nerve cooling did not cause any changes in arterial pressure. In the left kidney, blood flow, vascular conductance, sodium and water excretions increased, and renin release decreased. Simultaneously in the contralateral kidney, no haemodynamic changes were observed, glomerular filtration was only transiently decreased, whereas sodium and water excretion significantly decreased and renin release increased. When left renal nerve cooling was repeated after surgical denervation of the right kidney, similar changes were observed in the left (ipsilateral) kidney, whereas all contralateral effects were abolished. These experiments suggest that tonically active afferent fibres from one kidney exert a reflex inhibitory action on sympathetic activity directed to the contralateral kidney controlling tubular sodium reabsorption and renin release.

AB - In anaesthetized cats reversible denervation of one kidney was performed by cooling of the left renal nerves to 3°C for 16 min. The response of the left (ipsilateral) kidney was compared with the response of the right (contralateral) kidney twice in the same animal: (1) when the right kidney was still innervated, and (2) after it had been surgically denervated. Left renal nerve cooling did not cause any changes in arterial pressure. In the left kidney, blood flow, vascular conductance, sodium and water excretions increased, and renin release decreased. Simultaneously in the contralateral kidney, no haemodynamic changes were observed, glomerular filtration was only transiently decreased, whereas sodium and water excretion significantly decreased and renin release increased. When left renal nerve cooling was repeated after surgical denervation of the right kidney, similar changes were observed in the left (ipsilateral) kidney, whereas all contralateral effects were abolished. These experiments suggest that tonically active afferent fibres from one kidney exert a reflex inhibitory action on sympathetic activity directed to the contralateral kidney controlling tubular sodium reabsorption and renin release.

KW - Cooling

KW - Dieresis

KW - Natriuresis

KW - Renal nerves

KW - Rennin

KW - Renorenal reflexes

UR - http://www.scopus.com/inward/record.url?scp=0022704066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022704066&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 181

EP - 188

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 2

ER -