Effects of rivastigmine on motor and cognitive impairment in Huntington's disease

Marina de Tommaso, Nicola Specchio, Vittorio Sciruicchio, Olimpia Difruscolo, Luigi Maria Specchio

Research output: Contribution to journalArticle

Abstract

To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open-label, randomized, controlled study. Twenty-one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no-treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration.

Original languageEnglish
Pages (from-to)1516-1518
Number of pages3
JournalMovement Disorders
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Cognitive impairment
  • Huntington's disease
  • Motor
  • Rivastigmine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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