Effects of rivastigmine on motor and cognitive impairment in Huntington's disease

Marina de Tommaso, Nicola Specchio, Vittorio Sciruicchio, Olimpia Difruscolo, Luigi Maria Specchio

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open-label, randomized, controlled study. Twenty-one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no-treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration.

Original languageEnglish
Pages (from-to)1516-1518
Number of pages3
JournalMovement Disorders
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Rivastigmine
Huntington Disease
Cholinergic Agents
Demography
Cognitive Dysfunction

Keywords

  • Cognitive impairment
  • Huntington's disease
  • Motor
  • Rivastigmine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

de Tommaso, M., Specchio, N., Sciruicchio, V., Difruscolo, O., & Specchio, L. M. (2004). Effects of rivastigmine on motor and cognitive impairment in Huntington's disease. Movement Disorders, 19(12), 1516-1518. https://doi.org/10.1002/mds.20235

Effects of rivastigmine on motor and cognitive impairment in Huntington's disease. / de Tommaso, Marina; Specchio, Nicola; Sciruicchio, Vittorio; Difruscolo, Olimpia; Specchio, Luigi Maria.

In: Movement Disorders, Vol. 19, No. 12, 12.2004, p. 1516-1518.

Research output: Contribution to journalArticle

de Tommaso, M, Specchio, N, Sciruicchio, V, Difruscolo, O & Specchio, LM 2004, 'Effects of rivastigmine on motor and cognitive impairment in Huntington's disease', Movement Disorders, vol. 19, no. 12, pp. 1516-1518. https://doi.org/10.1002/mds.20235
de Tommaso, Marina ; Specchio, Nicola ; Sciruicchio, Vittorio ; Difruscolo, Olimpia ; Specchio, Luigi Maria. / Effects of rivastigmine on motor and cognitive impairment in Huntington's disease. In: Movement Disorders. 2004 ; Vol. 19, No. 12. pp. 1516-1518.
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