Effects of rivastigmine on visual attention in subjects with amnestic mild cognitive impairment: A serial functional MRI activation pilot-study

Arun L W Bokde, Enrica Cavedo, Patricia Lopez-Bayo, Simone Lista, Thomas Meindl, Christine Born, Samantha Galluzzi, Frank Faltraco, Bruno Dubois, Stefan J Teipel, Maximilian Reiser, Hans Jürgen Möller, Harald Hampel

Research output: Contribution to journalArticle

Abstract

A pilot study to investigate the effects of rivastigmine on the brain activation pattern due to visual attention tasks in a group of amnestic Mild Cognitive Impaired patients (aMCI). The design was an initial three-month double blind period with a rivastigmine and placebo arms, followed by a nine-month open-label period. All patients underwent serial functional magnetic resonance imaging (fMRI) at baseline, and after three and six months of follow-up. Primary endpoint was the effect of rivastigmine on functional brain changes during visual attention (face and location matching) tasks. There were five in the rivastigmine arm and two in the placebo arm. The face matching task showed higher activation of visual areas after three months of treatment but no differences compared to baseline at six months. The location matching task showed a higher activation along the dorsal visual pathway at both three and six months follow ups. Treatment with rivastigmine demonstrates a significant effect on brain activation of the dorsal visual pathway during a location matching task in patients with aMCI. Our data support the potential use of task fMRI to map specific treatment effects of cholinergic drugs during prodromal stages of Alzheimer's disease (AD).

Original languageEnglish
Pages (from-to)84-90
Number of pages7
JournalPsychiatry Research
Volume249
DOIs
Publication statusPublished - Mar 30 2016

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Rivastigmine
Magnetic Resonance Imaging
Arm
Visual Pathways
Brain
Placebos
Prodromal Symptoms
Cholinergic Agents
Alzheimer Disease
Therapeutics
Cognitive Dysfunction

Keywords

  • Aged
  • Aged, 80 and over
  • Amnesia
  • Attention
  • Brain
  • Brain Mapping
  • Cognitive Dysfunction
  • Double-Blind Method
  • Facial Recognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuroprotective Agents
  • Pilot Projects
  • Rivastigmine
  • Visual Pathways
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

Cite this

Effects of rivastigmine on visual attention in subjects with amnestic mild cognitive impairment : A serial functional MRI activation pilot-study. / Bokde, Arun L W; Cavedo, Enrica; Lopez-Bayo, Patricia; Lista, Simone; Meindl, Thomas; Born, Christine; Galluzzi, Samantha; Faltraco, Frank; Dubois, Bruno; Teipel, Stefan J; Reiser, Maximilian; Möller, Hans Jürgen; Hampel, Harald.

In: Psychiatry Research, Vol. 249, 30.03.2016, p. 84-90.

Research output: Contribution to journalArticle

Bokde, ALW, Cavedo, E, Lopez-Bayo, P, Lista, S, Meindl, T, Born, C, Galluzzi, S, Faltraco, F, Dubois, B, Teipel, SJ, Reiser, M, Möller, HJ & Hampel, H 2016, 'Effects of rivastigmine on visual attention in subjects with amnestic mild cognitive impairment: A serial functional MRI activation pilot-study', Psychiatry Research, vol. 249, pp. 84-90. https://doi.org/10.1016/j.pscychresns.2016.01.018
Bokde, Arun L W ; Cavedo, Enrica ; Lopez-Bayo, Patricia ; Lista, Simone ; Meindl, Thomas ; Born, Christine ; Galluzzi, Samantha ; Faltraco, Frank ; Dubois, Bruno ; Teipel, Stefan J ; Reiser, Maximilian ; Möller, Hans Jürgen ; Hampel, Harald. / Effects of rivastigmine on visual attention in subjects with amnestic mild cognitive impairment : A serial functional MRI activation pilot-study. In: Psychiatry Research. 2016 ; Vol. 249. pp. 84-90.
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AU - Lista, Simone

AU - Meindl, Thomas

AU - Born, Christine

AU - Galluzzi, Samantha

AU - Faltraco, Frank

AU - Dubois, Bruno

AU - Teipel, Stefan J

AU - Reiser, Maximilian

AU - Möller, Hans Jürgen

AU - Hampel, Harald

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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Y1 - 2016/3/30

N2 - A pilot study to investigate the effects of rivastigmine on the brain activation pattern due to visual attention tasks in a group of amnestic Mild Cognitive Impaired patients (aMCI). The design was an initial three-month double blind period with a rivastigmine and placebo arms, followed by a nine-month open-label period. All patients underwent serial functional magnetic resonance imaging (fMRI) at baseline, and after three and six months of follow-up. Primary endpoint was the effect of rivastigmine on functional brain changes during visual attention (face and location matching) tasks. There were five in the rivastigmine arm and two in the placebo arm. The face matching task showed higher activation of visual areas after three months of treatment but no differences compared to baseline at six months. The location matching task showed a higher activation along the dorsal visual pathway at both three and six months follow ups. Treatment with rivastigmine demonstrates a significant effect on brain activation of the dorsal visual pathway during a location matching task in patients with aMCI. Our data support the potential use of task fMRI to map specific treatment effects of cholinergic drugs during prodromal stages of Alzheimer's disease (AD).

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