Effects of robot assisted gait training in progressive supranuclear palsy (PSP): A preliminary report

Patrizio Sale, Fabrizio Stocchi, Daniele Galafate, Maria Francesca De Pandis, Domenica Le Pera, Ivan Sova, Manuela Galli, Calogero Foti, Marco Franceschini

Research output: Contribution to journalArticlepeer-review


Background and Purpose: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease clinically characterized by prominent axial extrapyramidal motor symptoms with frequent falls. Over the last years the introduction of robotic technologies to recover lower limb function has been greatly employed in the rehabilitative practice. This observational trial is aimed at investigating the changes in the main spatiotemporal following end-effector robot training in people with PSP. Method: Pilot observational trial. Participants: Five cognitively intact participants with PSP and gait disorders. Interventions: Patients were submitted to a rehabilitative program of robot-assisted walking sessions for 45 min, 5 times a week for 4 weeks. Main outcome measures: The spatiotemporal parameters at the beginning (T0) and at the end of treatment (T1) were recorded by a gait analysis laboratory. Results: Robot training was feasible, acceptable and safe and all participants completed the prescribed training sessions. All patients showed an improvement in the gait spatiotemporal index (Mean velocity, Cadence, Step length, and Step width) (T0 vs. T1). Conclusions: Robot training is a feasible and safe form of rehabilitation for cognitively intact people with PSP. The lack of side effects and the positive results in the gait parameter index in all patients support the recommendation to extend the trials of this treatment. Further investigation regarding the effectiveness of robot training in time is necessary.

Original languageEnglish
Article number207
JournalFrontiers in Human Neuroscience
Issue number1 APR
Publication statusPublished - Apr 17 2014


  • Gait analysis
  • Lower limb
  • Progressive supranuclear palsy
  • PSP
  • Robot

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology


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