TY - JOUR
T1 - Effects of salmon calcitonin suppositories in the prevention of bone loss in oophorectomized women
AU - Polatti, F.
AU - Perotti, F.
AU - Angelini, G. P.
AU - Vassellatti, D.
AU - Rapisardi, I.
PY - 1993
Y1 - 1993
N2 - To evaluate the efficacy of salmon calcitonin (sCT) suppositories in inhibiting postmenopausal bone demineralization and the tolerability of this formulation, we treated ten women oophorectomized in reproductive age with intrarectal sCT at the dose of 200 IU/day for 12 months postoperatively. Modifications of calcium and phosphate metabolism were quantified by measurements of vertebral and peripheral bone mineral content, serum alkaline phosphatase, and hydroxyprolinuria at baseline and at 6 and 12 months of treatment. Tolerability was assessed by recording the appearance of local or systemic side-effects. sCT suppositories were demonstrated to inhibit post-oophorectomy calcium loss, and tolerability was good.
AB - To evaluate the efficacy of salmon calcitonin (sCT) suppositories in inhibiting postmenopausal bone demineralization and the tolerability of this formulation, we treated ten women oophorectomized in reproductive age with intrarectal sCT at the dose of 200 IU/day for 12 months postoperatively. Modifications of calcium and phosphate metabolism were quantified by measurements of vertebral and peripheral bone mineral content, serum alkaline phosphatase, and hydroxyprolinuria at baseline and at 6 and 12 months of treatment. Tolerability was assessed by recording the appearance of local or systemic side-effects. sCT suppositories were demonstrated to inhibit post-oophorectomy calcium loss, and tolerability was good.
KW - Bone loss
KW - Oophorectomized women
KW - Salmon calcitonin suppository
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U2 - 10.1016/0378-5122(93)90031-C
DO - 10.1016/0378-5122(93)90031-C
M3 - Article
C2 - 8107619
AN - SCOPUS:0027743402
VL - 18
SP - 73
EP - 76
JO - Maturitas
JF - Maturitas
SN - 0378-5122
IS - 1
ER -