Effects of sauvagine on behavioural arousal of mice

F. Pavone; C. Castellano; A. Oliverio; P. Melchiorri; V. Erspamer

doi:10.1016/0196-9781(85)90351-1

Effects of sauvagine on behavioural arousal of mice

F. Pavone, C. Castellano, A. Oliverio, P. Melchiorri, V. Erspamer

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.

Original language	English
Pages (from-to)	59-61
Number of pages	3
Journal	Peptides
Volume	6
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/0196-9781(85)90351-1
Publication status	Published - 1985

Keywords

ECS-induced seizures
Endogenous opioids
Locomotor activity
Sauvagine

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0196-9781(85)90351-1

Fingerprint Dive into the research topics of 'Effects of sauvagine on behavioural arousal of mice'. Together they form a unique fingerprint.

Cite this

@article{ddae30fd2722453fa5e31d9e3d229d10,

title = "Effects of sauvagine on behavioural arousal of mice",

abstract = "The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.",

keywords = "ECS-induced seizures, Endogenous opioids, Locomotor activity, Sauvagine",

author = "F. Pavone and C. Castellano and A. Oliverio and P. Melchiorri and V. Erspamer",

year = "1985",

doi = "10.1016/0196-9781(85)90351-1",

language = "English",

volume = "6",

pages = "59--61",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "SUPPL. 3",

}

TY - JOUR

T1 - Effects of sauvagine on behavioural arousal of mice

AU - Pavone, F.

AU - Castellano, C.

AU - Oliverio, A.

AU - Melchiorri, P.

AU - Erspamer, V.

PY - 1985

Y1 - 1985

N2 - The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.

AB - The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.

KW - ECS-induced seizures

KW - Endogenous opioids

KW - Locomotor activity

KW - Sauvagine

UR - http://www.scopus.com/inward/record.url?scp=0022365995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022365995&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(85)90351-1

DO - 10.1016/0196-9781(85)90351-1

M3 - Article

C2 - 3831973

AN - SCOPUS:0022365995

VL - 6

SP - 59

EP - 61

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - SUPPL. 3

ER -