Effects of sauvagine on behavioural arousal of mice

F. Pavone, C. Castellano, A. Oliverio, P. Melchiorri, V. Erspamer

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.

Original languageEnglish
Pages (from-to)59-61
Number of pages3
JournalPeptides
Volume6
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 1985

Keywords

  • ECS-induced seizures
  • Endogenous opioids
  • Locomotor activity
  • Sauvagine

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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