Abstract
The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.
Original language | English |
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Pages (from-to) | 59-61 |
Number of pages | 3 |
Journal | Peptides |
Volume | 6 |
Issue number | SUPPL. 3 |
DOIs | |
Publication status | Published - 1985 |
Keywords
- ECS-induced seizures
- Endogenous opioids
- Locomotor activity
- Sauvagine
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience