Effects of sauvagine on behavioural arousal of mice

F. Pavone; C. Castellano; A. Oliverio; P. Melchiorri; V. Erspamer

doi:10.1016/0196-9781(85)90351-1

Effects of sauvagine on behavioural arousal of mice

F. Pavone, C. Castellano, A. Oliverio, P. Melchiorri, V. Erspamer

Fondazione Santa Lucia

Research output: Contribution to journal › Article

Abstract

The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.

Original language	English
Pages (from-to)	59-61
Number of pages	3
Journal	Peptides
Volume	6
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/0196-9781(85)90351-1
Publication status	Published - 1985

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Keywords

ECS-induced seizures
Endogenous opioids
Locomotor activity
Sauvagine

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

Cite this

Pavone, F., Castellano, C., Oliverio, A., Melchiorri, P., & Erspamer, V. (1985). Effects of sauvagine on behavioural arousal of mice. Peptides, 6(SUPPL. 3), 59-61. https://doi.org/10.1016/0196-9781(85)90351-1

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10.1016/0196-9781(85)90351-1