Fourty-two patients with grade II essential hypertension were studied. Eleven were treated with atenolol (100 mg/d), 11 with sotalol (160 mg/d) and 20 with mepindolol (10 mg/d). PRA, Total Renin (TR) (by tryptic activation), Inactive Renin (IR) and Urinary Aldosterone (UA) were measured before and after one and four weeks of treatment. Atenolol induced a slight but not significant reduction of all parameters while both sotalol and mepindolol significantly reduced PRA and UA after one (P2 type.
|Number of pages||7|
|Journal||Drugs under Experimental and Clinical Research|
|Publication status||Published - 1980|
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology (medical)
- Drug Discovery