Effects of selective and non-selective beta-blockers on inactive plasma renin in hypertensive patients

A. Rappelli, P. Dessi-Fulgheri, P. Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

Fourty-two patients with grade II essential hypertension were studied. Eleven were treated with atenolol (100 mg/d), 11 with sotalol (160 mg/d) and 20 with mepindolol (10 mg/d). PRA, Total Renin (TR) (by tryptic activation), Inactive Renin (IR) and Urinary Aldosterone (UA) were measured before and after one and four weeks of treatment. Atenolol induced a slight but not significant reduction of all parameters while both sotalol and mepindolol significantly reduced PRA and UA after one (P2 type.

Original languageEnglish
Pages (from-to)665-671
Number of pages7
JournalDrugs under Experimental and Clinical Research
Volume6
Issue number6
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

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