Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents

Maria Nobile, Barbara Begni, Roberto Giorda, Alessandra Frigerio, Cecilia Marino, Massimo Molteni, Carlo Ferrarese, Marco Battaglia

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate possible associations between serotonin transporter (5-HTT) promoter genotypic variants (I/I, I/s, and s/s) and differential regulation of platelet 5-HTT functionality parameters in a group of drug-naive depressed children and adolescents and healthy controls. Method: Children and adolescents with major depression (n = 18) defined by DSM-III-R criteria and normal controls (n = 21) were assessed both for platelet serotonin functionality and for genotypic variants on 5-HTT promoter region. Four parameters were considered: (1) serotonin uptake rate (V(max)); (2) serotonin dissociation constant (K(m)); (3) paroxetine binding and density of site (B(max)); and (4) paroxetine dissociation constant (K(d)). Results: Depressed children had lower V(max) and K(m). Control subjects with I/I genotype had significantly higher V(max) than control subjects with I/s and s/s genotype. Control subjects with I/I genotype also had significantly higher V(max) than their depressed homologs. In contrast, V(max) was not significantly different between depressed and nondepressed subjects who carried the other 2 genotypes. The 5-HTT promoter genotype, diagnoses, or their interaction had no effect on the other serotonin parameters. Conclusions: While showing a significant decrease of V(max) and K(m) in a group of drug-naive depressed children and adolescents, these data suggest that I/I genotype has a substantial effect on the decrease of V(max) during a depressive episode.

Original languageEnglish
Pages (from-to)1396-1402
Number of pages7
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume38
Issue number11
Publication statusPublished - 1999

Keywords

  • Genetic variants
  • Major depression
  • Platelet serotonin uptake
  • Serotonin transporter promoter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

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