Effects of sex on coronary microvascular dysfunction and cardiac outcomes

Venkatesh L. Murthy, Masanao Naya, Viviany R. Taqueti, Courtney R. Foster, Mariya Gaber, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Ornella Rimoldi, Paolo G. Camici, Marcelo F. Di Carli

Research output: Contribution to journalArticlepeer-review


BACKGROUND - Coronary microvascular dysfunction (CMD) is a prevalent and prognostically important finding in patients with symptoms suggestive of coronary artery disease. The relative extent to which CMD affects both sexes is largely unknown. METHODS AND RESULTS - We investigated 405 men and 813 women who were referred for evaluation of suspected coronary artery disease with no previous history of coronary artery disease and no visual evidence of coronary artery disease on rest/stress positron emission tomography myocardial perfusion imaging. Coronary flow reserve was quantified, and coronary flow reserve

Original languageEnglish
Pages (from-to)2518-2527
Number of pages10
Issue number24
Publication statusPublished - Jun 17 2014


  • Atherosclerosis
  • Blood flow velocity
  • Microcirculation
  • Sex
  • Women

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine


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